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Genome-wide effects of long-term divergent selection

Johansson, Anna M ; Pettersson, Mats E ; Siegel, Paul B ; Carlborg, Orjan Walsh, Bruce

PLoS genetics, 2010-11, Vol.6 (11), p.e1001188-e1001188 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Genome-wide effects of long-term divergent selection
Autor: Johansson, Anna M ; Pettersson, Mats E ; Siegel, Paul B ; Carlborg, Orjan
Walsh, Bruce
Assuntos: Alleles ; Animal and Dairy Science ; Animals ; Base Pairing - genetics ; Biologi ; Biology ; Body Weight - genetics ; Cell differentiation ; Chickens - genetics ; Chromosomes - genetics ; Computational Biology/Genomics ; Computational Biology/Molecular Genetics ; Computational Biology/Population Genetics ; Computer Simulation ; Evolution ; Evolution & development ; Experiments ; Gene Frequency - genetics ; Genetic aspects ; Genetic Loci - genetics ; Genetic markers ; Genetic Variation ; Genetics ; Genetics and Genomics/Animal Genetics ; Genetics and Genomics/Bioinformatics ; Genetics and Genomics/Complex Traits ; Genetics and Genomics/Physiogenomics ; Genetics and Genomics/Population Genetics ; Genome - genetics ; Genomes ; Genotype & phenotype ; Haplotypes ; Heterozygote ; Husdjursvetenskap ; NATURAL SCIENCES ; NATURVETENSKAP ; Polymorphism, Single Nucleotide - genetics ; Population ; Poultry ; Quantitative Trait, Heritable ; Selection, Genetic ; Single nucleotide polymorphisms ; Time Factors ; Veterinary Science ; Veterinärmedicin
É parte de: PLoS genetics, 2010-11, Vol.6 (11), p.e1001188-e1001188
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
Conceived and designed the experiments: AMJ MEP PBS ÖC. Analyzed the data: AMJ MEP ÖC. Contributed reagents/materials/analysis tools: AMJ MEP PBS. Wrote the paper: AMJ MEP PBS ÖC.
Descrição: To understand the genetic mechanisms leading to phenotypic differentiation, it is important to identify genomic regions under selection. We scanned the genome of two chicken lines from a single trait selection experiment, where 50 generations of selection have resulted in a 9-fold difference in body weight. Analyses of nearly 60,000 SNP markers showed that the effects of selection on the genome are dramatic. The lines were fixed for alternative alleles in more than 50 regions as a result of selection. Another 10 regions displayed strong evidence for ongoing differentiation during the last 10 generations. Many more regions across the genome showed large differences in allele frequency between the lines, indicating that the phenotypic evolution in the lines in 50 generations is the result of an exploitation of standing genetic variation at 100s of loci across the genome.
Editor: United States: Public Library of Science
Idioma: Inglês

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Genome-wide effects of long-term divergent selection

Johansson, Anna M ; Pettersson, Mats E ; Siegel, Paul B ; Carlborg, Orjan Walsh, Bruce

United States: Public Library of Science

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