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Survival Analysis of the Surgical Outcome of Temporal Lobe Epilepsy Due to Hippocampal Sclerosis

Paglioli, Eliseu ; Palmini, André ; Paglioli, Eduardo ; Da Costa, Jaderson C. ; Portuguez, Mirna ; Martinez, José V. ; Calcagnotto, Maria E. ; Hoefel, João R. ; Raupp, Sergio ; Barbosa‐Coutinho, Ligia

Epilepsia (Copenhagen), 2004-11, Vol.45 (11), p.1383-1391 [Periódico revisado por pares]

350 Main Street , Malden , MA 02148 , USA and 9600 Garsington Road , Oxford , OX4 2XG , England: Blackwell Science Inc

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Título:
Survival Analysis of the Surgical Outcome of Temporal Lobe Epilepsy Due to Hippocampal Sclerosis
Autor: Paglioli, Eliseu ; Palmini, André ; Paglioli, Eduardo ; Da Costa, Jaderson C. ; Portuguez, Mirna ; Martinez, José V. ; Calcagnotto, Maria E. ; Hoefel, João R. ; Raupp, Sergio ; Barbosa‐Coutinho, Ligia
Assuntos: Adolescent ; Adult ; Age of Onset ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biological and medical sciences ; Brain Diseases - diagnostic imaging ; Brain Diseases - epidemiology ; Brain Diseases - pathology ; Child ; Comorbidity ; Cross-Sectional Studies ; Epilepsy surgery ; Epilepsy, Temporal Lobe - diagnostic imaging ; Epilepsy, Temporal Lobe - epidemiology ; Epilepsy, Temporal Lobe - surgery ; Female ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Hippocampal scleosis ; Hippocampus - pathology ; Humans ; Longitudinal Studies ; Long‐term outcome ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; Nervous system (semeiology, syndromes) ; Neurology ; Neuropharmacology ; Neuropsychological Tests ; Neurosurgery ; Pharmacology. Drug treatments ; Radionuclide Imaging ; Sclerosis ; Skull, brain, vascular surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Survival Analysis ; Temporal Lobe epilepsy ; Treatment Outcome
É parte de: Epilepsia (Copenhagen), 2004-11, Vol.45 (11), p.1383-1391
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SourceType-Scholarly Journals-1
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Descrição: Purpose: Surgical results in patients with mesial temporal lobe epilepsy due to hippocampal sclerosis (MTLE/HS) are often reported in conjunction with other etiologies of TLE. Methods: We prospectively collected surgical outcome data for 2 to 11 years for 134 consecutive patients who specifically had MTLE and unilateral HS, according to magnetic resonance imaging (MRI) and confirmed by histopathology. Sixty‐five had postoperative neuropsychological testing. Outcome was analyzed by using Engel's classification (a) through Kaplan–Meier estimated survival curves (as a function of the time to seizure recurrence), (b) as percentage of patients in each outcome class on a yearly basis, and (c) at the last updated follow‐up. Results: Kaplan–Meier estimates of complete seizure freedom (Engel's class IA) for years 1, 2, 5, and 10 were 85%, 77%, 74%, and 66%, and of Engel's class I were 89%, 86%, 83%, and 81%. Only nine (6.7%) patients had outcome classes III or IV at any point during follow‐up. Of the patients tested, 26% of those operated on the left side and 22% of those operated on the right had postoperative decline of >1 SD in verbal or visual memory, respectively. Conclusions: High rates of seizure freedom can be obtained and remain stable over the years in patients operated on for unilateral MTLE/HS, even in countries with limited resources.
Editor: 350 Main Street , Malden , MA 02148 , USA and 9600 Garsington Road , Oxford , OX4 2XG , England: Blackwell Science Inc
Idioma: Inglês

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Survival Analysis of the Surgical Outcome of Temporal Lobe Epilepsy Due to Hippocampal Sclerosis

Paglioli, Eliseu ; Palmini, André ; Paglioli, Eduardo ; Da Costa, Jaderson C. ; Portuguez, Mirna ; Martinez, José V. ; Calcagnotto, Maria E. ; Hoefel, João R. ; Raupp, Sergio ; Barbosa‐Coutinho, Ligia

350 Main Street , Malden , MA 02148 , USA and 9600 Garsington Road , Oxford , OX4 2XG , England: Blackwell Science Inc

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