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What do we know about the role of menopause in cardiovascular autonomic regulation in hypertensive women?

Philbois, Stella V ; Facioli, Tabata P ; De Lucca, Izabella ; Veiga, Ana C ; Chinellato, Naiara ; Simões, Marcus V ; Tank, Jens ; Souza, Hugo C D

Menopause (New York, N.Y.), 2024-05, Vol.31 (5), p.408-414 [Periódico revisado por pares]

United States

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  • Título:
    What do we know about the role of menopause in cardiovascular autonomic regulation in hypertensive women?
  • Autor: Philbois, Stella V ; Facioli, Tabata P ; De Lucca, Izabella ; Veiga, Ana C ; Chinellato, Naiara ; Simões, Marcus V ; Tank, Jens ; Souza, Hugo C D
  • Assuntos: Adult ; Autonomic Nervous System - physiology ; Autonomic Nervous System - physiopathology ; Baroreflex - physiology ; Blood Pressure - physiology ; Cardiorespiratory Fitness - physiology ; Cardiovascular System - physiopathology ; Female ; Heart Rate - physiology ; Humans ; Hypertension - physiopathology ; Menopause - physiology ; Middle Aged ; Postmenopause - physiology ; Premenopause - physiology
  • É parte de: Menopause (New York, N.Y.), 2024-05, Vol.31 (5), p.408-414
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: We investigated the systemic arterial hypertension effects on cardiovascular autonomic modulation and baroreflex sensitivity (BRS) in women with or without preserved ovarian function. A total of 120 women were allocated into two groups: middle-aged premenopausal women (42 ± 3 y old; n = 60) and postmenopausal women (57 ± 4 y old; n = 60). Each group was also divided into two smaller groups (n = 30): normotensive and hypertensive. We evaluated hemodynamic and anthropometric parameters, cardiorespiratory fitness, BRS, heart rate variability (HRV), and blood pressure variability. The effects of hypertension and menopause were assessed using a two-way analysis of variance. Post hoc comparisons were performed using the Student-Newman-Keuls test. Comparing premenopausal groups, women with systemic arterial hypertension showed lower BRS (9.1 ± 4.4 vs 13.4 ± 4.2 ms/mm Hg, P < 0.001 ) and HRV total variance (1,451 ± 955 vs 2,483 ± 1,959 ms 2 , P = 0.005) values than normotensive; however, the vagal predominance still remained. On the other hand, both postmenopausal groups showed an expressive reduction in BRS (8.3 ± 4.2 vs 11.3 ± 4.8 ms/mm Hg, P < 0.001) and HRV characterized by sympathetic modulation predominance (low-frequency oscillations; 56% ± 17 vs 44% ± 17, P < 0.001), in addition to a significant increase in blood pressure variability variance (28.4 ± 14.9 vs 22.4 ± 12.5 mm Hg 2 , P = 0.015) compared with premenopausal groups. Comparing both postmenopausal groups, the hypertensive group had significantly lower values ​​of HRV total variance (635 ± 449 vs 2,053 ± 1,720 ms 2 , P < 0.001) and BRS (5.3 ± 2.8 vs 11.3 ± 3.2 ms/mm Hg) than the normotensive. Hypertensive middle-aged premenopausal women present HRV autonomic modulation impairment, but they still maintain a vagal predominance. After menopause, even normotensive women show sympathetic autonomic predominance, which may also be associated with aging. Furthermore, postmenopausal women with hypertension present even worse cardiac autonomic modulation.
  • Editor: United States
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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