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Physalis angulata extract exerts anti-inflammatory effects in rats by inhibiting different pathways

Bastos, G.N.T. ; Silveira, A.J.A. ; Salgado, C.G. ; Picanço-Diniz, D.L.W. ; do Nascimento, J.L.M.

Journal of ethnopharmacology, 2008-07, Vol.118 (2), p.246-251 [Periódico revisado por pares]

Shannon: Elsevier Ireland Ltd

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Título:
Physalis angulata extract exerts anti-inflammatory effects in rats by inhibiting different pathways
Autor: Bastos, G.N.T. ; Silveira, A.J.A. ; Salgado, C.G. ; Picanço-Diniz, D.L.W. ; do Nascimento, J.L.M.
Assuntos: Adenosine deaminase ; Adenosine Deaminase - drug effects ; Adenosine Deaminase - metabolism ; Amazon ethnopharmacology ; animal models ; Animals ; anti-inflammatory activity ; Anti-Inflammatory Agents - administration & dosage ; Anti-Inflammatory Agents - isolation & purification ; Anti-Inflammatory Agents - pharmacology ; Anti-inflammatory response ; biochemical pathways ; Biological and medical sciences ; biomarkers ; Brazil ; Dinoprostone - metabolism ; Dose-Response Relationship, Drug ; General pharmacology ; growth factors ; herbal medicines ; Indomethacin - pharmacology ; inflammation ; Inflammation - drug therapy ; lymphocyte proliferation ; Lymphocytes - drug effects ; Lymphocytes - metabolism ; Male ; mechanism of action ; Medical sciences ; medicinal plants ; Medicine, Traditional ; Nitric oxide ; Nitric Oxide - metabolism ; nitrites ; nitrous oxide ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Physalis - chemistry ; Physalis angulata ; Physalis angulata L ; plant extracts ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Plant Roots ; Prostaglandin E ; prostaglandin synthase ; prostaglandins ; protective effect ; Rats ; Rats, Wistar ; roots ; TGF-β ; Transforming Growth Factor beta - drug effects ; Transforming Growth Factor beta - metabolism ; tumor growth factor-beta ; Up-Regulation - drug effects
É parte de: Journal of ethnopharmacology, 2008-07, Vol.118 (2), p.246-251
Notas: http://dx.doi.org/10.1016/j.jep.2008.04.005
ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Physalis angulata is a popular medicine used in Brazil due to its anti-inflammatory effects, but the pharmacological mechanisms underlying these actions remain to be better understood. In the present work, lyophilized aqueous extract from the roots of Physalis angulata Linneu (AEPa) was used to control the inflammatory response induced by the injection of 1% carrageenan into subcutaneous rat's air pouches. Adenosine deaminase (ADA) activity, nitrite level, and prostaglandin E 2 (PGE 2) level were used to evaluate the action of inflammatory mediators. Tumor growth factor-β (TGF-β) level was used as a bioindicator of immunomodulatory response. Rats were injected with vehicle, indomethacin, or AEPa (0.5 mg/kg, 1 mg/kg, and 5 mg/kg i.p.), 1 h before carrageenan administration. AEPa at 0.5 mg/kg had no effect. However, 1 mg/kg of AEPa showed significant anti-inflammatory effects, decreasing exudate volume, total number of inflammatory cells, ADA activity, nitrite level, and PGE 2 level in 50%, 41%, 20%, 60%, and 41%, respectively. The anti-inflammatory effects of 5 mg/kg AEPa appeared to be more effective than those of 1 mg/kg AEPa (84%, 80%, 43%, 70%, and 75%, respectively). In addition, TGF-β level was upregulated to 9700 pg/ml after 5 mg/kg AEPa, in comparison with 160 pg/ml in the vehicle-treated group, and 137 pg/ml in the indomethacin-treated group. The results indicate that AEPa exerts powerful anti-inflammatory and immunomodulatory activities, interfering with the cyclooxygenase pathway, lymphocyte proliferation, NO, and TGF-β production.
Editor: Shannon: Elsevier Ireland Ltd
Idioma: Inglês

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Physalis angulata extract exerts anti-inflammatory effects in rats by inhibiting different pathways

Bastos, G.N.T. ; Silveira, A.J.A. ; Salgado, C.G. ; Picanço-Diniz, D.L.W. ; do Nascimento, J.L.M.

Shannon: Elsevier Ireland Ltd

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