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Vasopressin and the regulation of aquaporin-2

Wilson, Justin L. L. ; Miranda, Carlos A. ; Knepper, Mark A.

Clinical and experimental nephrology, 2013-12, Vol.17 (6), p.751-764 [Periódico revisado por pares]

Tokyo: Springer Japan

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Título:
Vasopressin and the regulation of aquaporin-2
Autor: Wilson, Justin L. L. ; Miranda, Carlos A. ; Knepper, Mark A.
Assuntos: Animals ; Aquaporin 2 - biosynthesis ; Aquaporin 2 - metabolism ; beta Catenin - metabolism ; Cyclic AMP - physiology ; Cyclic AMP-Dependent Protein Kinases - metabolism ; Heart Failure - physiopathology ; Humans ; Inappropriate ADH Syndrome - physiopathology ; Kidney Tubules, Collecting - metabolism ; Liver Cirrhosis - physiopathology ; Medicine ; Medicine & Public Health ; Mice ; Myosin-Light-Chain Kinase - metabolism ; Nephrology ; Nephrotic Syndrome - physiopathology ; Permeability ; Phosphoproteins - metabolism ; Phosphorylation - drug effects ; Polyuria - physiopathology ; Proto-Oncogene Proteins c-akt - metabolism ; Proto-Oncogene Proteins c-jun - metabolism ; Rats ; Review Article ; Signal Transduction - physiology ; Transcription Factor AP-1 - metabolism ; Transcription Factors - physiology ; Urology ; Vasopressins - physiology
É parte de: Clinical and experimental nephrology, 2013-12, Vol.17 (6), p.751-764
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Water excretion is regulated in large part through the regulation of osmotic water permeability of the renal collecting duct epithelium. Water permeability is controlled by vasopressin through regulation of the water channel, aquaporin-2 (AQP2). Two processes contribute: (1) regulation of AQP2 trafficking to the apical plasma membrane; and (2) regulation of the total amount of the AQP2 protein in the cells. Regulation of AQP2 abundance is defective in several water-balance disorders, including many polyuric disorders and the syndrome of inappropriate antidiuresis. Here we review vasopressin signaling in the renal collecting duct that is relevant to the two modes of water permeability regulation.
Editor: Tokyo: Springer Japan
Idioma: Inglês

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Vasopressin and the regulation of aquaporin-2

Wilson, Justin L. L. ; Miranda, Carlos A. ; Knepper, Mark A.

Tokyo: Springer Japan

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