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Education, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancer

R.V.M. López ; M.A. Zago ; J. Eluf-Neto ; M.P. Curado ; A.W. Daudt ; W.A. da Silva-Junior ; D.L. Zanette ; J.E. Levi ; M.B. de Carvalho ; L.P. Kowalski ; M. Abrahão ; J.F. de Góis-Filho ; P. Boffetta ; V. Wünsch-Filho

Brazilian journal of medical and biological research, 2011-10, Vol.44 (10), p.1006-1012 [Periódico revisado por pares]

Associação Brasileira de Divulgação Científica

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  • Título:
    Education, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancer
  • Autor: R.V.M. López ; M.A. Zago ; J. Eluf-Neto ; M.P. Curado ; A.W. Daudt ; W.A. da Silva-Junior ; D.L. Zanette ; J.E. Levi ; M.B. de Carvalho ; L.P. Kowalski ; M. Abrahão ; J.F. de Góis-Filho ; P. Boffetta ; V. Wünsch-Filho
  • Assuntos: Alcohol ; Cancer prognosis ; Head and neck cancer ; Interleukin ; Smoking ; Survival analysis
  • É parte de: Brazilian journal of medical and biological research, 2011-10, Vol.44 (10), p.1006-1012
  • Descrição: The association of education, tobacco smoking, alcohol consumption, and interleukin-2 (IL-2 +114 and -384) and -6 (IL-6 -174) DNA polymorphisms with head and neck squamous cell carcinoma (HNSCC) was investigated in a cohort study of 445 subjects. IL-2 and IL-6 genotypes were determined by real-time PCR. Cox regression was used to estimate hazard ratios (HR) and 95% confidence intervals (95%CI) of disease-specific survival according to anatomical sites of the head and neck. Mean age was 56 years and most patients were males (87.6%). Subjects with 5 or more years of schooling had better survival in larynx cancer. Smoking had no effect on HNSCC survival, but alcohol consumption had a statistically significant effect on larynx cancer. IL-2 gene +114 G/T (HR = 0.52; 95%CI = 0.15-1.81) and T/T (HR = 0.22; 95%CI = 0.02-3.19) genotypes were associated with better survival in hypopharynx cancer. IL-2 +114 G/T was a predictor of poor survival in oral cavity/oropharynx cancer and larynx cancer (HR = 1.32; 95%CI = 0.61-2.85). IL-2 -384 G/T was associated with better survival in oral cavity/oropharynx cancer (HR = 0.80; 95%CI = 0.45-1.42) and hypopharynx cancer (HR = 0.68; 95%CI = 0.21-2.20), but an inverse relationship was observed for larynx cancer. IL-6 -174 G/C was associated with better survival in hypopharynx cancer (HR = 0.68; 95%CI = 0.26-1.78) and larynx cancer (HR = 0.93; 95%CI = 0.42-2.07), and C/C reduced mortality in larynx cancer. In general, our results are similar to previous reports on the value of education, smoking, alcohol consumption, and IL-2 and IL-6 genetic polymorphisms for the prognosis of HNSCC, but the risks due to these variables are small and estimates imprecise.
  • Editor: Associação Brasileira de Divulgação Científica
  • Idioma: Inglês

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