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An investigation into the teratogenic potential of captan, folpet, and Difolatan in nonhuman primates

Vondruska, James F. ; Fancher, Otis E. ; Calandra, J.C.

Toxicology and applied pharmacology, 1971-03, Vol.18 (3), p.619-624 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
An investigation into the teratogenic potential of captan, folpet, and Difolatan in nonhuman primates
Autor: Vondruska, James F. ; Fancher, Otis E. ; Calandra, J.C.
Assuntos: Abnormalities, Drug-Induced ; Animals ; Antifungal Agents - administration & dosage ; Antifungal Agents - toxicity ; Female ; Fetus - drug effects ; Haplorhini ; Humerus - abnormalities ; Indoles - administration & dosage ; Indoles - toxicity ; Ketones - toxicity ; Limb Deformities, Congenital ; Pregnancy ; Radius - abnormalities ; Ribs - abnormalities ; Sulfides - toxicity ; Thalidomide - toxicity ; Ulna - abnormalities
É parte de: Toxicology and applied pharmacology, 1971-03, Vol.18 (3), p.619-624
Descrição: Captan and folpet were administered to pregnant rhesus monkeys and stump-tailed macaques, and Difolatan was administered to pregnant rhesus monkeys in order to assess the teratogenic potential of these compounds for nonhuman primates. Susceptibility to the teratogenic effects of thalidomide was confirmed for the rhesus monkey and established for the stump-tailed macaque. Dosing with thalidomide and the 3 experimental compounds was carried out during the period of fetal limb development. Abnormal fetuses were observed following administration of thalidomide but not after captan, folpet, or Difolatan. Thus the present study produced no evidence that captan, folpet, and Difolatan possess teratogenic potential for nonhuman primates.
Editor: United States: Elsevier Inc
Idioma: Inglês

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An investigation into the teratogenic potential of captan, folpet, and Difolatan in nonhuman primates

Vondruska, James F. ; Fancher, Otis E. ; Calandra, J.C.

United States: Elsevier Inc

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