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Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy

NAGAYA, Noritoshi ; KANGAWA, Kenji ; TOKUDOME, Takeshi ; MQRI, Hidezo ; MIYATAKE, Kunio ; KITAMURA, Soichiro ; ITOH, Takefumi ; IWASE, Takashi ; MURAKAMI, Shinsuke ; MIYAHARA, Yoshinori ; FUJII, Takafumi ; UEMATSU, Masaaki ; OHGUSHI, Hajime ; YAMAGISHI, Masakazu

Circulation (New York, N.Y.), 2005-08, Vol.112 (8), p.1128-1135 [Periódico revisado por pares]

Hagerstown, MD: Lippincott Williams & Wilkins

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Título:
Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy
Autor: NAGAYA, Noritoshi ; KANGAWA, Kenji ; TOKUDOME, Takeshi ; MQRI, Hidezo ; MIYATAKE, Kunio ; KITAMURA, Soichiro ; ITOH, Takefumi ; IWASE, Takashi ; MURAKAMI, Shinsuke ; MIYAHARA, Yoshinori ; FUJII, Takafumi ; UEMATSU, Masaaki ; OHGUSHI, Hajime ; YAMAGISHI, Masakazu
Assuntos: Animals ; Apoptosis ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood vessels and receptors ; Bone Marrow Cells - cytology ; Cardiology. Vascular system ; Cardiomyopathy, Dilated - diagnostic imaging ; Cardiomyopathy, Dilated - pathology ; Cardiomyopathy, Dilated - therapy ; Cell Differentiation ; Cells, Cultured ; Disease Models, Animal ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Endocrinopathies ; Fibrosis ; Fundamental and applied biological sciences. Psychology ; Growth Substances - metabolism ; Male ; Medical sciences ; Mesenchymal Stem Cell Transplantation ; Mesoderm - cytology ; Mesoderm - metabolism ; Myocardial Contraction ; Myocytes, Cardiac - cytology ; Myocytes, Cardiac - physiology ; Neovascularization, Physiologic ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Pluripotent Stem Cells - cytology ; Pluripotent Stem Cells - metabolism ; Rats ; Rats, Inbred Lew ; Thyroid. Thyroid axis (diseases) ; Ultrasonography ; Vertebrates: cardiovascular system
É parte de: Circulation (New York, N.Y.), 2005-08, Vol.112 (8), p.1128-1135
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Pluripotent mesenchymal stem cells (MSCs) differentiate into a variety of cells, including cardiomyocytes and vascular endothelial cells. However, little information is available about the therapeutic potency of MSC transplantation in cases of dilated cardiomyopathy (DCM), an important cause of heart failure. We investigated whether transplanted MSCs induce myogenesis and angiogenesis and improve cardiac function in a rat model of DCM. MSCs were isolated from bone marrow aspirates of isogenic adult rats and expanded ex vivo. Cultured MSCs secreted large amounts of the angiogenic, antiapoptotic, and mitogenic factors vascular endothelial growth factor, hepatocyte growth factor, adrenomedullin, and insulin-like growth factor-1. Five weeks after immunization, MSCs or vehicle was injected into the myocardium. Some engrafted MSCs were positive for the cardiac markers desmin, cardiac troponin T, and connexin-43, whereas others formed vascular structures and were positive for von Willebrand factor or smooth muscle actin. Compared with vehicle injection, MSC transplantation significantly increased capillary density and decreased the collagen volume fraction in the myocardium, resulting in decreased left ventricular end-diastolic pressure (11+/-1 versus 16+/-1 mm Hg, P<0.05) and increased left ventricular maximum dP/dt (6767+/-323 versus 5138+/-280 mm Hg/s, P<0.05). MSC transplantation improved cardiac function in a rat model of DCM, possibly through induction of myogenesis and angiogenesis, as well as by inhibition of myocardial fibrosis. The beneficial effects of MSCs might be mediated not only by their differentiation into cardiomyocytes and vascular cells but also by their ability to supply large amounts of angiogenic, antiapoptotic, and mitogenic factors.
Editor: Hagerstown, MD: Lippincott Williams & Wilkins
Idioma: Inglês

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Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy

NAGAYA, Noritoshi ; KANGAWA, Kenji ; TOKUDOME, Takeshi ; MQRI, Hidezo ; MIYATAKE, Kunio ; KITAMURA, Soichiro ; ITOH, Takefumi ; IWASE, Takashi ; MURAKAMI, Shinsuke ; MIYAHARA, Yoshinori ; FUJII, Takafumi ; UEMATSU, Masaaki ; OHGUSHI, Hajime ; YAMAGISHI, Masakazu

Hagerstown, MD: Lippincott Williams & Wilkins

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