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Voltage‐gated calcium channel nanodomains: molecular composition and function

Gandini, Maria A. ; Zamponi, Gerald W.

The FEBS journal, 2022-02, Vol.289 (3), p.614-633 [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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Título:
Voltage‐gated calcium channel nanodomains: molecular composition and function
Autor: Gandini, Maria A. ; Zamponi, Gerald W.
Assuntos: 14‐3‐3 ; BK channel ; Calcium - metabolism ; Calcium channels ; Calcium channels (voltage-gated) ; Calcium Channels - genetics ; Calcium influx ; Calcium ions ; Calcium Signaling - genetics ; Calcium-Binding Proteins - genetics ; CaV2 channels ; Channels ; Chemical composition ; Electric potential ; Humans ; neurexin ; Neurons - metabolism ; Neurotransmission ; Neurotransmitters ; Peptides ; Presynaptic Terminals - metabolism ; Proteins ; Reviews ; RIM ; RIM‐BP ; SNAP‐25 ; Synapses - genetics ; Synaptic cleft ; Synaptic Transmission - genetics ; synaptotagmin ; syntaxin ; Tethering ; Vesicle fusion ; Voltage
É parte de: The FEBS journal, 2022-02, Vol.289 (3), p.614-633
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Voltage‐gated calcium (CaV) channels and their regulation by proteins at the synaptic cleft play a critical role in neurotransmission. These interactions fine‐tune the synaptic response through the regulation of Ca2+ entry into the presynaptic terminal and trigger the fusion of vesicles filled with neurotransmitters and peptides. Regulation of CaV channel intrinsic properties and their numbers at the active zones shape the timing and strength of synaptic function. Here, we provide an overview of a number of proteins reported to be part of CaV channel nanodomains at the synaptic cleft and the repercussions of these interactions for CaV channel trafficking, tethering at the active zone, and regulation of their biophysical properties. We summarize the current state of knowledge by which CaV channels are regulated at presynaptic sites. Voltage‐gated calcium channel nanodomains are formed through interactions with a number of different proteins that are involved in diverse functions. From the cytoskeleton to active zone proteins, each interaction has a specific role in neurotransmission. In this review, Gandini and Zamponi summarize current understanding of how calcium channels are trafficked, tethered at the active zone, and the functional implications of these interactions.
Editor: England: Blackwell Publishing Ltd
Idioma: Inglês

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Voltage‐gated calcium channel nanodomains: molecular composition and function

Gandini, Maria A. ; Zamponi, Gerald W.

England: Blackwell Publishing Ltd

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