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The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015

Bhatt, S ; Weiss, D J ; Cameron, E ; Bisanzio, D ; Mappin, B ; Dalrymple, U ; Battle, K ; Moyes, C L ; Henry, A ; Eckhoff, P A ; Wenger, E A ; Briët, O ; Penny, M A ; Smith, T A ; Bennett, A ; Yukich, J ; Eisele, T P ; Griffin, J T ; Fergus, C A ; Lynch, M ; Lindgren, F ; Cohen, J M ; Murray, C L J ; Smith, D L ; Hay, S I ; Cibulskis, R E ; Gething, P W

Nature (London), 2015-10, Vol.526 (7572), p.207-211 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015
Autor: Bhatt, S ; Weiss, D J ; Cameron, E ; Bisanzio, D ; Mappin, B ; Dalrymple, U ; Battle, K ; Moyes, C L ; Henry, A ; Eckhoff, P A ; Wenger, E A ; Briët, O ; Penny, M A ; Smith, T A ; Bennett, A ; Yukich, J ; Eisele, T P ; Griffin, J T ; Fergus, C A ; Lynch, M ; Lindgren, F ; Cohen, J M ; Murray, C L J ; Smith, D L ; Hay, S I ; Cibulskis, R E ; Gething, P W
Assuntos: Africa - epidemiology ; Animals ; Antimalarials - therapeutic use ; Child ; Child, Preschool ; Databases, Factual ; Disease control ; Distribution ; Drug Resistance ; Endemic Diseases - prevention & control ; Endemic Diseases - statistics & numerical data ; Environmental aspects ; Humans ; Incidence ; Infection control ; Infections ; Insecticide-Treated Bednets - statistics & numerical data ; Insecticides ; Intervention ; Malaria ; Malaria, Falciparum - drug therapy ; Malaria, Falciparum - epidemiology ; Malaria, Falciparum - parasitology ; Malaria, Falciparum - prevention & control ; Medical research ; Medicine, Experimental ; Medicine, Preventive ; Parasites ; Plasmodium falciparum ; Plasmodium falciparum - drug effects ; Prevalence ; Prevention ; Preventive health services ; Risk Assessment ; Studies
É parte de: Nature (London), 2015-10, Vol.526 (7572), p.207-211
Notas: Author Contributions Conceived of and designed the research: PWG and SB. Drafted the manuscript: PWG and SB. Drafted the supplementary information: SB, DJW, EC, DB, UD, BM. Prepared data: SB, DJW, BM, UD, KB, CLM, AH, AB, JY, TPE. Conducted the analyses: SB, DJW, EC, DB, CAF, ML, REC. Supported the analyses: PAE, EAW, OB, MAP, TAS, JTG, CAF, ML, FL, DLS. Supported interpretation and policy contextualization: SB, AB, TPE, JY, CAF, ML, JMC, CLJM, DLS, SIH, REC, PWG. All authors discussed the results and contributed to the revision of the final manuscript.
Descrição: Since the year 2000, a concerted campaign against malaria has led to unprecedented levels of intervention coverage across sub-Saharan Africa. Understanding the effect of this control effort is vital to inform future control planning. However, the effect of malaria interventions across the varied epidemiological settings of Africa remains poorly understood owing to the absence of reliable surveillance data and the simplistic approaches underlying current disease estimates. Here we link a large database of malaria field surveys with detailed reconstructions of changing intervention coverage to directly evaluate trends from 2000 to 2015, and quantify the attributable effect of malaria disease control efforts. We found that Plasmodium falciparum infection prevalence in endemic Africa halved and the incidence of clinical disease fell by 40% between 2000 and 2015. We estimate that interventions have averted 663 (542-753 credible interval) million clinical cases since 2000. Insecticide-treated nets, the most widespread intervention, were by far the largest contributor (68% of cases averted). Although still below target levels, current malaria interventions have substantially reduced malaria disease incidence across the continent. Increasing access to these interventions, and maintaining their effectiveness in the face of insecticide and drug resistance, should form a cornerstone of post-2015 control strategies.
Editor: England: Nature Publishing Group
Idioma: Inglês

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The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015

England: Nature Publishing Group

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