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Sensory-Related Neural Activity Regulates the Structure of Vascular Networks in the Cerebral Cortex

Lacoste, Baptiste ; Comin, Cesar H. ; Ben-Zvi, Ayal ; Kaeser, Pascal S. ; Xu, Xiaoyin ; Costa, Luciano da F. ; Gu, Chenghua

Neuron (Cambridge, Mass.), 2014-09, Vol.83 (5), p.1117-1130 [Peer Reviewed Journal]

United States: Elsevier Inc

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Title:
Sensory-Related Neural Activity Regulates the Structure of Vascular Networks in the Cerebral Cortex
Author: Lacoste, Baptiste ; Comin, Cesar H. ; Ben-Zvi, Ayal ; Kaeser, Pascal S. ; Xu, Xiaoyin ; Costa, Luciano da F. ; Gu, Chenghua
Subjects: Afferent Pathways - physiology ; Age Factors ; Animals ; Animals, Newborn ; Cell Proliferation ; Cerebral Cortex - cytology ; Cerebral Cortex - physiology ; Cerebrovascular Circulation - physiology ; Gene Expression Regulation, Developmental - genetics ; Grants ; GTP-Binding Proteins - genetics ; GTP-Binding Proteins - metabolism ; In Vitro Techniques ; Luminescent Proteins - genetics ; Luminescent Proteins - metabolism ; Metabolism ; Mice ; Mice, Transgenic ; Neurobiology ; Neurons ; Neurosciences ; Phosphopyruvate Hydratase - metabolism ; Physical Stimulation ; rab3 GTP-Binding Proteins - genetics ; Receptor, TIE-2 - genetics ; Receptor, TIE-2 - metabolism ; Rodents ; Scholarships & fellowships ; Sensory Receptor Cells - physiology ; Statistical methods ; Vibrissae - injuries ; Vibrissae - physiology
Is Part Of: Neuron (Cambridge, Mass.), 2014-09, Vol.83 (5), p.1117-1130
Notes: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Description: Neurovascular interactions are essential for proper brain function. While the effect of neural activity on cerebral blood flow has been extensively studied, whether or not neural activity influences vascular patterning remains elusive. Here, we demonstrate that neural activity promotes the formation of vascular networks in the early postnatal mouse barrel cortex. Using a combination of genetics, imaging, and computational tools to allow simultaneous analysis of neuronal and vascular components, we found that vascular density and branching were decreased in the barrel cortex when sensory input was reduced by either a complete deafferentation, a genetic impairment of neurotransmitter release at thalamocortical synapses, or a selective reduction of sensory-related neural activity by whisker plucking. In contrast, enhancement of neural activity by whisker stimulation led to an increase in vascular density and branching. The finding that neural activity is necessary and sufficient to trigger alterations of vascular networks reveals an important feature of neurovascular interactions. [Display omitted] •Neural activity promotes the formation of vascular networks in the cerebral cortex•Sensory deprivation reduces vascular complexity in layer IV of the barrel cortex•Genetic impairment of neurotransmitter release impairs cortical vascular structure•Activity induced vascular changes occur in absence of neuroarchitectural changes Using genetic, imaging, and computational tools, Lacoste et al. demonstrate that “natural” neural activity triggered by sensory stimuli enhances the complexity of vascular networks in the mouse cerebral cortex during postnatal development.
Publisher: United States: Elsevier Inc
Language: English

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Sensory-Related Neural Activity Regulates the Structure of Vascular Networks in the Cerebral Cortex

Lacoste, Baptiste ; Comin, Cesar H. ; Ben-Zvi, Ayal ; Kaeser, Pascal S. ; Xu, Xiaoyin ; Costa, Luciano da F. ; Gu, Chenghua

United States: Elsevier Inc

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