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Immunohistochemical expression of plasminogen activator inhibitor-1 in subcutaneous versus omental adipose tissue in patients after elective abdominal surgery

Yildiz, Mehmet; Bozkurtlar, Emine; Azizy, Abdulmunir; Agirbasli, Mehmet

Autopsy and Case Reports; Vol. 9 Núm. 4 (2019); e2019121

Universidade de São Paulo. Hospital Universitário 2019-10-03

Acesso online

  • Título:
    Immunohistochemical expression of plasminogen activator inhibitor-1 in subcutaneous versus omental adipose tissue in patients after elective abdominal surgery
  • Autor: Yildiz, Mehmet; Bozkurtlar, Emine; Azizy, Abdulmunir; Agirbasli, Mehmet
  • Assuntos: Adipose Tissue; Immunohistochemistry; Plasminogen Activator Inhibitor-1
  • É parte de: Autopsy and Case Reports; Vol. 9 Núm. 4 (2019); e2019121
  • Descrição: Plasminogen activator inhibitor-1 (PAI-1) is a biomarker of thrombosis. Adipose and vascular tissues are among the major sources of PAI-1 production. Previous studies indicated that fat deposits mediate increased cardiovascular risk among obese individuals. We investigated the immunohistochemical (IHC) expression of PAI-1 in adipose and vascular tissues from the omentum and the subcutaneous tissue. The pathology samples were selected from 37 random patients who underwent elective abdominal surgery between 2008-2009. PAI-1 expression was semi-quantitatively scored and compared between the groups. Significant differences were noted in the IHC expression of PAI-1 between the omental and the subcutaneous adipose tissues (1.1 ± 0.8 versus 0.8 ± 0.6, respectively (p=0.05)). Adipose tissue displayed higher IHC expression of PAI-1 compared to vascular wall tissue in both omentum and subcutaneous sections (1.1 ± 0.8 versus 0.5 ± 0.9 (p=0.004), and 0.8 ± 0.6 versus 0.4 ± 0.6 (p=0.003), respectively). In conclusion, our study compared PAI-1 expression in the omentum versus the subcutaneous tissue and adipose versus vascular tissues. IHC expression of PAI-1 level was significantly higher in the omental adipose tissue compared to the subcutaneous adipose tissue. Adipose tissue displayed significantly higher PAI-1 expression than vascular tissue. The study elucidates the biological differences of adipose and vascular tissue from subcutaneous versus omental sections.
  • Títulos relacionados: https://www.revistas.usp.br/autopsy/article/view/162883/156649; https://www.revistas.usp.br/autopsy/article/view/162883/156650
  • Editor: Universidade de São Paulo. Hospital Universitário
  • Data de criação/publicação: 2019-10-03
  • Formato: Adobe PDF
  • Idioma: Inglês
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