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Genomic insights into the c-di-GMP signaling and biofilm development in the saprophytic spirochete Leptospira biflexa

Vasconcelos, Larissa ; Aburjaile, Flávia ; Andrade, Lara ; Cancio, Artur Filipe ; Seyffert, Núbia ; Aguiar, Eric R. G. R. ; Ristow, Paula

Archives of microbiology, 2023-05, Vol.205 (5), p.180-180, Article 180 [Periódico revisado por pares]

Berlin/Heidelberg: Springer Berlin Heidelberg

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Título:
Genomic insights into the c-di-GMP signaling and biofilm development in the saprophytic spirochete Leptospira biflexa
Autor: Vasconcelos, Larissa ; Aburjaile, Flávia ; Andrade, Lara ; Cancio, Artur Filipe ; Seyffert, Núbia ; Aguiar, Eric R. G. R. ; Ristow, Paula
Assuntos: Bacteria ; Bacteria - metabolism ; Bacterial Proteins - genetics ; Bacterial Proteins - metabolism ; Biochemistry ; Biofilms ; Biomedical and Life Sciences ; Biotechnology ; Cell Biology ; Ecology ; Escherichia coli Proteins - genetics ; Flagella ; Gene Expression Regulation, Bacterial ; Genomic analysis ; Genomics ; Kidneys ; Leptospira ; Leptospira - genetics ; Leptospira - metabolism ; Leptospira biflexa ; Life Sciences ; Medical importance ; Microbial Ecology ; Microbiology ; Original Paper ; Proteins ; Signalling systems ; Species diversity ; Spirochaetales - metabolism ; Spirochetes
É parte de: Archives of microbiology, 2023-05, Vol.205 (5), p.180-180, Article 180
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: C-di-GMP is a bacterial second messenger with central role in biofilm formation. Spirochete bacteria from Leptospira genus present a wide diversity, with species of medical importance and environmental species, named as saprophytic. Leptospira form biofilms in the rat’s reservoir kidneys and in the environment. Here, we performed genomic analyses to identify enzymatic and effector c-di-GMP proteins in the saprophytic biofilm-forming species Leptospira biflexa serovar Patoc. We identified 40 proteins through local alignments. Amongst them, 16 proteins are potentially functional diguanylate cyclases, phosphodiesterases, or hybrid proteins. We also identified nine effectors, including PilZ proteins. Enrichment analyses suggested that c-di-GMP interacts with cAMP signaling system, CsrA system, and flagella assembly regulation during biofilm development of L. biflexa . Finally, we identified eight proteins in the pathogen Leptospira interrogans serovar Copenhageni that share high similarity with L. biflexa c-di-GMP-related proteins. This work revealed proteins related to c-di-GMP turnover and cellular response in Leptospira and their potential roles during biofilm development.
Editor: Berlin/Heidelberg: Springer Berlin Heidelberg
Idioma: Inglês

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Genomic insights into the c-di-GMP signaling and biofilm development in the saprophytic spirochete Leptospira biflexa

Vasconcelos, Larissa ; Aburjaile, Flávia ; Andrade, Lara ; Cancio, Artur Filipe ; Seyffert, Núbia ; Aguiar, Eric R. G. R. ; Ristow, Paula

Berlin/Heidelberg: Springer Berlin Heidelberg

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