Idioma:

Preparation of Certified Methodology for Testing Transdermal Absorption of Chemicals In Vitro

Kotingová, Lenka ; Nývltová, Zora ; Rösslerová, Zdeňka ; Bíšková, Lucie ; Volková, Jana ; Fibír, Aleš ; Kořínková, Jaroslava ; Moravcová, Lenka ; Plodíková, Petra

Chemické listy, 2022-12, Vol.116 (12), p.751-758 [Periódico revisado por pares]

Texto completo disponível

Citações Citado por

Título:
Preparation of Certified Methodology for Testing Transdermal Absorption of Chemicals In Vitro
Autor: Kotingová, Lenka ; Nývltová, Zora ; Rösslerová, Zdeňka ; Bíšková, Lucie ; Volková, Jana ; Fibír, Aleš ; Kořínková, Jaroslava ; Moravcová, Lenka ; Plodíková, Petra
É parte de: Chemické listy, 2022-12, Vol.116 (12), p.751-758
Descrição: This publication presents the preparation of a certified methodology for in vitro transdermal absorption testing of chemicals and highlights the various pitfalls in their implementation. Vertical diffusion cells (Franz cells) were used to test the dermal absorption of caffeine, benzoic acid, and testosterone across a penetration membrane (porcine ear skin), while the receptor fluid samples were evaluated by HPLC. The designed methodology was certified in 2022 in the Good Laboratory Practice system and will be used at the VUOS Rybitví and at the Medical Faculty of the Charles University in Hradec Králové to assess the dermal absorption of various substances in the environment and occupational surroundings.
Idioma: Inglês

Voltar para lista de resultados

Anterior Resultado 5 Avançar Ir para próxima página