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Vitamin D status and functional parameters: A cross-sectional study in an older population

Mendes, J ; Santos, A ; Borges, N ; Afonso, C ; Moreira, P ; Padrão, P ; Negrão, R ; Amaral, T F Zmijewski, Michal

PloS one, 2018-08, Vol.13 (8), p.e0201840-e0201840 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Vitamin D status and functional parameters: A cross-sectional study in an older population
Autor: Mendes, J ; Santos, A ; Borges, N ; Afonso, C ; Moreira, P ; Padrão, P ; Negrão, R ; Amaral, T F
Zmijewski, Michal
Assuntos: 25-Hydroxyvitamin D ; Adults ; Aged ; Alfacalcidol ; Analysis ; Biology and Life Sciences ; Calcifediol ; Causation ; Cross-sectional studies ; Dependent variables ; Dietary supplements ; Elderly ; Electrochemiluminescence ; Exercise ; Food and nutrition ; Gait ; Grip strength ; Hand ; Health aspects ; Immunoassay ; Medicine and health sciences ; Mortality ; Nutrient deficiency ; Nutrition ; Older people ; People and Places ; Phenotypes ; Physical sciences ; Physiological aspects ; Population studies ; Quality of life ; Quartiles ; Risk ; Serum levels ; Skin diseases ; Vitamin D ; Vitamin deficiency
É parte de: PloS one, 2018-08, Vol.13 (8), p.e0201840-e0201840
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Competing Interests: The authors have declared that no competing interests exist.
Descrição: The present study aims to clarify the association of vitamin D status with functionality, measured through gait speed and hand grip strength, in a sample of older adults, considering sex-specific characteristics and the potential confounding effect of lifestyle factors, disease, skin phenotype, season of blood collection and vitamin D supplementation. The Nutrition UP 65 cross-sectional study was conducted in a population-based sample of 1,425 older adults ≥ 65 years old. Serum levels of 25-hydroxyvitamin D were quantified through electrochemiluminescence immunoassay. Multinomial logistic regressions were carried out using quartiles of gait speed and of hand grip strength as dependent variables. Participants at risk of vitamin D inadequacy (30.0-49.9 nmol/L) and deficiency (< 30.0 nmol/L) presented higher adjusted odds ratio of the lowest values of gait speed and hand grip strength than those with adequate vitamin D levels (≥ 50.0 nmol/L). These associations were strongest among men at risk of vitamin D deficiency [adjusted odds ratio for the lowest quartile of gait speed = 3.24; 95% CI: 1.56-6.73 and for the lowest quartile of hand grip strength = 3.28; 95% CI: 1.47-7.31] than in women at risk of vitamin D deficiency [adjusted odds ratio for the lowest quartile of gait speed = 2.72; 95% CI: 1.37-5.41 and for the lowest quartile of hand grip strength = 1.56; 95% CI: 0.81-3.00]. In conclusion, in older adults, particularly in men, the risk of vitamin D deficiency was directly associated with the lowest values of gait speed and of hand grip strength. However, randomized controlled trials are needed to overcome the possibility of reverse causation and residual confounding. Present results emphasise the need for strategies to promote the reduction of the high prevalence of low vitamin D status among the Portuguese older adult population.
Editor: United States: Public Library of Science
Idioma: Inglês

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Vitamin D status and functional parameters: A cross-sectional study in an older population

Mendes, J ; Santos, A ; Borges, N ; Afonso, C ; Moreira, P ; Padrão, P ; Negrão, R ; Amaral, T F Zmijewski, Michal

United States: Public Library of Science

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