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Molecular Genetic Analyses of the Tyrolean Ice Man

Handt, Oliva ; Richards, Martin ; Trommsdorff, Marion ; Kilger, Christian ; Simanainen, Jaana ; Georgiev, Oleg ; Bauer, Karin ; Stone, Anne ; Hedges, Robert ; Schaffner, Walter ; Utermann, Gerd ; Sykes, Bryan ; Pääbo, Svante

Science (American Association for the Advancement of Science), 1994-06, Vol.264 (5166), p.1775-1778 [Periódico revisado por pares]

Washington, DC: American Society for the Advancement of Science

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Título:
Molecular Genetic Analyses of the Tyrolean Ice Man
Autor: Handt, Oliva ; Richards, Martin ; Trommsdorff, Marion ; Kilger, Christian ; Simanainen, Jaana ; Georgiev, Oleg ; Bauer, Karin ; Stone, Anne ; Hedges, Robert ; Schaffner, Walter ; Utermann, Gerd ; Sykes, Bryan ; Pääbo, Svante
Assuntos: amplification ; Animals ; Anthropology ; Austria ; Base Sequence ; Biological and medical sciences ; Biological Evolution ; Bone and Bones - chemistry ; Connective Tissue - chemistry ; DNA ; DNA, Mitochondrial - chemistry ; DNA, Mitochondrial - genetics ; Europe ; Freezing ; Fundamental and applied biological sciences. Psychology ; genes ; genetic analysis ; Genetics ; Genetics of eukaryotes. Biological and molecular evolution ; Genomes ; History of medicine ; History, Ancient ; Hominidae - genetics ; Human population genetics ; Humans ; Ice ; Male ; man ; mitochondria ; Mitochondrial DNA ; Molecular genetics ; Molecular Sequence Data ; Molecules ; Mummies ; Muscles - chemistry ; Nucleotides ; Polymerase Chain Reaction ; Prehistoric peoples ; Sequence Analysis, DNA ; Space life sciences ; Templates, Genetic ; Tissue samples ; Tyrolean Alps
É parte de: Science (American Association for the Advancement of Science), 1994-06, Vol.264 (5166), p.1775-1778
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Descrição: An approximately 5000-year-old mummified human body was recently found in the Tyrolean Alps. The DNA from tissue samples of this Late Neolithic individual, the so-called "Ice Man," has been extracted and analyzed. The number of DNA molecules surviving in the tissue was on the order of 10 genome equivalents per gram of tissue, which meant that only multi-copy sequences could be analyzed. The degradation of the DNA made the enzymatic amplification of mitochondrial DNA fragments of more than 100 to 200 base pairs difficult. One DNA sequence of a hypervariable segment of the mitochondrial control region was determined independently in two different laboratories from internal samples of the body. This sequence showed that the mitochondrial type of the Ice Man fits into the genetic variation of contemporary Europeans and that it was most closely related to mitochondrial types determined from central and northern European populations.
Editor: Washington, DC: American Society for the Advancement of Science
Idioma: Inglês

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Molecular Genetic Analyses of the Tyrolean Ice Man

Handt, Oliva ; Richards, Martin ; Trommsdorff, Marion ; Kilger, Christian ; Simanainen, Jaana ; Georgiev, Oleg ; Bauer, Karin ; Stone, Anne ; Hedges, Robert ; Schaffner, Walter ; Utermann, Gerd ; Sykes, Bryan ; Pääbo, Svante

Washington, DC: American Society for the Advancement of Science

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