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Clinical Significance of Thrombospondin 1 Expression in Hepatocellular Carcinoma

Poon, Ronnie T ; Chung, Ka Kit ; Cheung, Siu Tim ; Lau, Cecilia P ; Tong, See Wai ; Leung, Ka Ling ; Yu, Wan Ching ; Tuszynski, George P ; Fan, Sheung Tat

Clinical cancer research, 2004-06, Vol.10 (12), p.4150-4157 [Periódico revisado por pares]

Philadelphia, PA: American Association for Cancer Research

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Título:
Clinical Significance of Thrombospondin 1 Expression in Hepatocellular Carcinoma
Autor: Poon, Ronnie T ; Chung, Ka Kit ; Cheung, Siu Tim ; Lau, Cecilia P ; Tong, See Wai ; Leung, Ka Ling ; Yu, Wan Ching ; Tuszynski, George P ; Fan, Sheung Tat
Assuntos: Aged ; Antineoplastic agents ; Biological and medical sciences ; Carcinoma, Hepatocellular - metabolism ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Immunohistochemistry ; Liver Neoplasms - metabolism ; Male ; Medical sciences ; Middle Aged ; Neovascularization, Pathologic ; Pharmacology. Drug treatments ; Prognosis ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - metabolism ; Thrombospondin 1 - biosynthesis ; Time Factors ; Treatment Outcome ; Tumors ; Vascular Endothelial Growth Factor A - biosynthesis
É parte de: Clinical cancer research, 2004-06, Vol.10 (12), p.4150-4157
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Purpose: Thrombospondin 1 (THBS 1) is a matricellular protein capable of modulating angiogenesis. However, the actual role of THBS 1 in angiogenesis and tumor progression remains controversial. Hepatocellular carcinoma (HCC) is a hypervascular tumor characterized by neovascularization. The significance of THBS 1 in HCC remains unknown. In this study, the significance of THBS 1 in HCC was evaluated by correlating its expression with clinicopathological data. The possible role of THBS 1 in the angiogenesis of HCC was also studied by correlating its expression with vascular endothelial growth factor (VEGF) expression. Experimental Design: Sixty HCC patients were recruited in this study. THBS 1 and VEGF protein expression in tumorous livers were localized by immunohistochemical staining and quantified by ELISA. THBS 1 mRNA was quantified by quantitative reverse transcription-PCR. Results: Immunohistochemical staining of THBS 1 was positive in HCC cells in 51.7% of patients and in stromal cells in 65% of patients. Tumor THBS 1 protein level was significantly correlated with its mRNA expression ( P = 0.001) and was significantly correlated with tumor VEGF protein levels ( P = 0.001). Its expression was significantly associated with the presence of venous invasion ( P = 0.008) and advanced tumor stage ( P = 0.049). High THBS 1 expression was also a prognostic marker of poor survival in HCC patients. Conclusions: This study shows that high expression of THBS 1 is associated with tumor invasiveness and progression in HCC. THBS 1 appears to be a proangiogenic factor that stimulates angiogenesis in HCC in view of its positive correlation with VEGF expression.
Editor: Philadelphia, PA: American Association for Cancer Research
Idioma: Inglês

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Clinical Significance of Thrombospondin 1 Expression in Hepatocellular Carcinoma

Poon, Ronnie T ; Chung, Ka Kit ; Cheung, Siu Tim ; Lau, Cecilia P ; Tong, See Wai ; Leung, Ka Ling ; Yu, Wan Ching ; Tuszynski, George P ; Fan, Sheung Tat

Philadelphia, PA: American Association for Cancer Research

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