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Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study

Roemer, Frank W ; Guermazi, Ali ; Felson, David T ; Niu, Jingbo ; Nevitt, Michael C ; Crema, Michel D ; Lynch, John A ; Lewis, Cora E ; Torner, James ; Zhang, Yuqing

Annals of the rheumatic diseases, 2011-10, Vol.70 (10), p.1804-1809 [Periódico revisado por pares]

London: BMJ Publishing Group Ltd and European League Against Rheumatism

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Título:
Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study
Autor: Roemer, Frank W ; Guermazi, Ali ; Felson, David T ; Niu, Jingbo ; Nevitt, Michael C ; Crema, Michel D ; Lynch, John A ; Lewis, Cora E ; Torner, James ; Zhang, Yuqing
Assuntos: Aged ; Biological and medical sciences ; Cartilage diseases ; Cartilage, Articular - pathology ; Disease ; Disease Progression ; Diseases of the osteoarticular system ; Effusion ; Exudates and Transudates - metabolism ; Female ; Follow-Up Studies ; Humans ; Inflammation ; Inversion ; Joint diseases ; Joints ; Knee ; Knee Joint - metabolism ; Knee Joint - pathology ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Middle Aged ; Miscellaneous. Osteoarticular involvement in other diseases ; Osteoarthritis ; Osteoarthritis, Knee - pathology ; Pain ; Protons ; Rheumatoid arthritis ; Skin cancer ; Studies ; Synovitis ; Synovitis - metabolism ; Synovitis - pathology
É parte de: Annals of the rheumatic diseases, 2011-10, Vol.70 (10), p.1804-1809
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Descrição: Objective To evaluate if two different measures of synovial activation, baseline Hoffa synovitis and effusion synovitis, assessed by MRI, predict cartilage loss in the tibiofemoral joint at 30 months follow-up in subjects with neither cartilage damage nor tibiofemoral radiographic osteoarthritis of the knee. Methods Non-contrast-enhanced MRI was performed using proton density-weighted fat-suppressed sequences in the axial and sagittal planes and a short tau inversion recovery sequence in the coronal plane. Hoffa synovitis, effusion synovitis and cartilage status were assessed semiquantitatively according to the WORMS scoring system. Included were knees that had neither radiographic osteoarthritis nor MRI-detected tibiofemoral cartilage damage at the baseline visit. The presence of Hoffa synovitis was defined as any grade ≥2 (range 0–3) and effusion synovitis as any grade ≥2 (range 0–3). Logistic regression was performed to examine the relation of the presence of either measure to the risk of cartilage loss at 30 months adjusting for other potential confounders. Results Of 514 knees included in the analysis, the prevalence of Hoffa synovitis and effusion synovitis at the baseline visit was 8.4% and 10.3%, respectively. In the multivariable analysis, baseline effusion synovitis was associated with an increased risk of cartilage loss. No such association was observed for baseline Hoffa synovitis. Conclusions Baseline effusion synovitis, but not Hoffa synovitis, predicted cartilage loss. The findings suggest that effusion synovitis, a reflection of inflammatory activity including joint effusion and synovitic thickening, may play a role in the future development of cartilage lesions in knees without osteoarthritis.
Editor: London: BMJ Publishing Group Ltd and European League Against Rheumatism
Idioma: Inglês

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Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study

Roemer, Frank W ; Guermazi, Ali ; Felson, David T ; Niu, Jingbo ; Nevitt, Michael C ; Crema, Michel D ; Lynch, John A ; Lewis, Cora E ; Torner, James ; Zhang, Yuqing

London: BMJ Publishing Group Ltd and European League Against Rheumatism

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