skip to main content
Primo Search
Search in: Busca Geral
Tipo de recurso Mostra resultados com: Mostra resultados com: Índice

Probing function in 3D neuronal cultures: a survey of 3D multielectrode array advances

Lam, Doris ; Fischer, Nicholas O. ; Enright, Heather A.

United States 2021

Sem texto completo

Citações Citado por
  • Título:
    Probing function in 3D neuronal cultures: a survey of 3D multielectrode array advances
  • Autor: Lam, Doris ; Fischer, Nicholas O. ; Enright, Heather A.
  • Assuntos: BASIC BIOLOGICAL SCIENCES ; Biological and medical sciences
  • Notas: AC52-07NA27344
    LLNL-TR-823576
    USDOE Laboratory Directed Research and Development (LDRD) Program
    USDOE National Nuclear Security Administration (NNSA)
  • Descrição: Recent advances in microphysiological systems (MPS) have made significant strides to include design features that reconstruct key elements found in the brain, and in parallel advanced technologies to detect the activity of electrogenic cells that form neural networks. In particular, three-dimensional multielectrode arrays (3D MEAs) are being developed with the increasing levels of spatial and temporal precision, difficult to achieve with current 2D MEAs, insertable MEA probes, and/or optical imaging of calcium dynamics. Thus, providing a means to monitor the flow of neural network activity within all three dimensions (X, Y, and Z) of the engineered tissue. In the last 6 years, 3D MEAs, using either “bottom-up” or “top-down” designs, have been developed to overcome the current technical challenges in monitoring the functionality of the in vitro systems. Herein, we will report on the design and application of novel 3D MEA prototypes for probing neural activity throughout the 3D neural tissue.
  • Editor: United States
  • Data de criação/publicação: 2021
  • Idioma: Inglês

Buscando em bases de dados remotas. Favor aguardar.