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Human antibody response to a pneumococcal vaccine in SCID‐PBL‐hu mice and simultaneously vaccinated human cell donors

AABERGE, I. S. ; STEINSVIK, T. E. ; GROENG, E.‐C. ; LEIKVOLD, R.‐B. ; LØVIK, M.

Clinical and experimental immunology, 1996-07, Vol.105 (1), p.12-17 [Periódico revisado por pares]

Oxford BSL: Blackwell Science Ltd

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Título:
Human antibody response to a pneumococcal vaccine in SCID‐PBL‐hu mice and simultaneously vaccinated human cell donors
Autor: AABERGE, I. S. ; STEINSVIK, T. E. ; GROENG, E.‐C. ; LEIKVOLD, R.‐B. ; LØVIK, M.
Assuntos: Adult ; Animals ; Antibodies, Bacterial - biosynthesis ; anti‐polysaccharide antibodies ; Bacterial Vaccines - administration & dosage ; Bacterial Vaccines - immunology ; Biological and medical sciences ; Experimental and animal immunopathology. Animal models ; Humans ; Immunization Schedule ; Immunoglobulin A - biosynthesis ; Immunoglobulin G - biosynthesis ; Immunoglobulin M - biosynthesis ; Immunopathology ; Lymphocyte Transfusion ; Male ; Medical sciences ; Mice ; Mice, SCID ; pneumococcal vaccine ; Pneumococcal Vaccines ; Rapid Publications ; SCID ; SCID‐PBL‐hu ; Species Specificity ; Streptococcus pneumoniae ; Streptococcus pneumoniae - immunology ; Transplantation, Heterologous
É parte de: Clinical and experimental immunology, 1996-07, Vol.105 (1), p.12-17
Notas: ObjectType-Article-2
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Descrição: Severe combined immunodeficient (SCID) mice were transplanted intraperitoneally with human peripheral blood lymphocytes (PBL) from nine healthy human donors (SCID‐PBL‐hu mice). None of the donors had ever received pneumococcal vaccine. Ten days after transplantation, 62 out of 111 transplanted mice and six of the nine donors were vaccinated with a 23‐valent pneumococcal polysaccharide vaccine. For each donor, human IgG was detected in 91.7–100% of the SCID‐PBL‐hu mice, whereas specific human IgG antipneumococcal antibodies were demonstrated in 16.7–100% of the vaccinated SCID‐PBL‐hu mice. Most of the mice transplanted with cells from the same donor showed similar antibody response patterns in terms of kinetics and antibody levels. A significant antibody response was only obtained in mice that received cells from donors with relatively high antipneumococcal antibody levels at the time of transplantation, or donors that showed a substantial increase in antibody levels after vaccination. The immune response in the SCID‐PBL‐hu mice did not always reflect the ability of the respective donor to produce antipneumococcal antibodies. The donor dependency of the antipneumococcal antibody response has great practical importance for the use of the SCID‐PBL‐hu model. Donors should not be chosen randomly. By selecting donors whose cells have been found to result in successful engraftment, functional SCID‐PBL‐hu mice can be obtained for the study of human immune responses and function in an in vivo experimental model.
Editor: Oxford BSL: Blackwell Science Ltd
Idioma: Inglês

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Human antibody response to a pneumococcal vaccine in SCID‐PBL‐hu mice and simultaneously vaccinated human cell donors

AABERGE, I. S. ; STEINSVIK, T. E. ; GROENG, E.‐C. ; LEIKVOLD, R.‐B. ; LØVIK, M.

Oxford BSL: Blackwell Science Ltd

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