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Inhibition of uterine motility by aminophylline

Coutinho, Elsimar M. ; Lopes, A.C.Vieira

American journal of obstetrics and gynecology, 1971-07, Vol.110 (5), p.726-729 [Periódico revisado por pares]

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Título:
Inhibition of uterine motility by aminophylline
Autor: Coutinho, Elsimar M. ; Lopes, A.C.Vieira
Assuntos: Aminophylline - pharmacology ; Blood Pressure ; Cyclic AMP - metabolism ; Female ; Humans ; Menstruation ; Muscle Contraction - drug effects ; Muscle, Smooth - drug effects ; Phosphoric Monoester Hydrolases - metabolism ; Pulse ; Uterus - drug effects
É parte de: American journal of obstetrics and gynecology, 1971-07, Vol.110 (5), p.726-729
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Aminophylline, a dimethylxanthine derivative used as a vascular smooth-muscle relaxant and diuretic, was administered to 60 patients at various stages of the menstrual cycle. Uterine activity was depressed and sometimes completely abolished by aminophylline. The uterine response was marked during the late proliferative and the early secretory phases. During menstruation, inhibition of motility was less intense than during other stages of the cycle. It is proposed that the inhibitory effects of aminophylline on the uterus are correlated with cyclic adenosine 3′,5′-monophosphate accumulation through inhibition of the enzyme phosphodiesterase.
Editor: United States: Elsevier Inc
Idioma: Inglês

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