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Epstein-Barr virus maintains lymphomas via its miRNAs

Vereide, D T ; Seto, E ; Chiu, Y-F ; Hayes, M ; Tagawa, T ; Grundhoff, A ; Hammerschmidt, W ; Sugden, B

Oncogene, 2014-03, Vol.33 (10), p.1258-1264 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Epstein-Barr virus maintains lymphomas via its miRNAs
Autor: Vereide, D T ; Seto, E ; Chiu, Y-F ; Hayes, M ; Tagawa, T ; Grundhoff, A ; Hammerschmidt, W ; Sugden, B
Assuntos: Apoptosis ; B-Lymphocytes - enzymology ; B-Lymphocytes - physiology ; B-Lymphocytes - virology ; Base Sequence ; Binding Sites ; Burkitt Lymphoma - metabolism ; Burkitt Lymphoma - pathology ; Burkitt Lymphoma - virology ; Burkitt's lymphoma ; Caspase 3 - genetics ; Caspase 3 - metabolism ; Caspase-3 ; Cell Line, Tumor ; Cell Proliferation ; Cell Survival ; Epstein-Barr virus ; Epstein-Barr Virus Nuclear Antigens - genetics ; Gene Expression Regulation, Neoplastic ; Genetic aspects ; Herpesvirus 4, Human - physiology ; Host-Pathogen Interactions ; Humans ; Latency ; Lymphocytes B ; Lymphoma ; Lymphomas ; MicroRNA ; MicroRNAs - genetics ; miRNA ; Oncology ; Physiological aspects ; Ribonucleic acid ; RNA ; RNA Interference ; Viruses
É parte de: Oncogene, 2014-03, Vol.33 (10), p.1258-1264
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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Descrição: Epstein-Barr virus (EBV) has evolved exquisite controls over its host cells, human B lymphocytes, not only directing these cells during latency to proliferate and thereby expand the pool of infected cells, but also to survive and thereby persist for the lifetime of the infected individual. Although these activities ensure the virus is successful, they also make the virus oncogenic, particularly when infected people are immunosuppressed. Here we show, strikingly, that one set of EBV's microRNAs (miRNAs) both sustain Burkitt's lymphoma (BL) cells in the absence of other viral oncogenes and promote the transformation of primary B lymphocytes. BL cells were engineered to lose EBV and found to die by apoptosis and could be rescued by constitutively expressing viral miRNAs in them. Two of these EBV miRNAs were found to target caspase 3 to inhibit apoptosis at physiological concentrations.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Epstein-Barr virus maintains lymphomas via its miRNAs

Vereide, D T ; Seto, E ; Chiu, Y-F ; Hayes, M ; Tagawa, T ; Grundhoff, A ; Hammerschmidt, W ; Sugden, B

England: Nature Publishing Group

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