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Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites

Holloway, J Kim ; Sun, Xianfei ; Yokoo, Rayka ; Villeneuve, Anne M ; Cohen, Paula E

The Journal of cell biology, 2014-06, Vol.205 (5), p.633-641 [Periódico revisado por pares]

United States: Rockefeller University Press

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Título:
Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites
Autor: Holloway, J Kim ; Sun, Xianfei ; Yokoo, Rayka ; Villeneuve, Anne M ; Cohen, Paula E
Assuntos: Animals ; Cell Differentiation ; Chromosome Segregation ; Chromosomes - ultrastructure ; Crossing Over, Genetic ; Cyclins - genetics ; Cyclins - physiology ; DNA Breaks, Double-Stranded ; Genes ; Genetics ; Ligases - metabolism ; Male ; Mammals ; Maturation ; Meiosis ; Mice ; Mice, Transgenic ; Mutation ; Phenotype ; Proteins ; Recombination, Genetic ; Sperm Count ; Spermatocytes - cytology ; Spermatocytes - metabolism ; Ubiquitin-Protein Ligases - metabolism
É parte de: The Journal of cell biology, 2014-06, Vol.205 (5), p.633-641
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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J.K. Holloway and X. Sun contributed equally to this paper.
Descrição: Meiotic crossovers (COs) are crucial for ensuring accurate homologous chromosome segregation during meiosis I. Because the double-strand breaks (DSBs) that initiate meiotic recombination greatly outnumber eventual COs, this process requires exquisite regulation to narrow down the pool of DSB intermediates that may form COs. In this paper, we identify a cyclin-related protein, CNTD1, as a critical mediator of this process. Disruption of Cntd1 results in failure to localize CO-specific factors MutLγ and HEI10 at designated CO sites and also leads to prolonged high levels of pre-CO intermediates marked by MutSγ and RNF212. These data show that maturation of COs is intimately coupled to deselection of excess pre-CO sites to yield a limited number of COs and that CNTD1 coordinates these processes by regulating the association between the RING finger proteins HEI10 and RNF212 and components of the CO machinery.
Editor: United States: Rockefeller University Press
Idioma: Inglês

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Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites

Holloway, J Kim ; Sun, Xianfei ; Yokoo, Rayka ; Villeneuve, Anne M ; Cohen, Paula E

United States: Rockefeller University Press

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