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An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice

Castro, João Pl ; Yancoskie, Michelle N ; Marchini, Marta ; Belohlavy, Stefanie ; Hiramatsu, Layla ; Kučka, Marek ; Beluch, William H ; Naumann, Ronald ; Skuplik, Isabella ; Cobb, John ; Barton, Nicholas H ; Rolian, Campbell ; Chan, Yingguang Frank

eLife, 2019-06, Vol.8 [Periódico revisado por pares]

England: eLife Science Publications, Ltd

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Título:
An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice
Autor: Castro, João Pl ; Yancoskie, Michelle N ; Marchini, Marta ; Belohlavy, Stefanie ; Hiramatsu, Layla ; Kučka, Marek ; Beluch, William H ; Naumann, Ronald ; Skuplik, Isabella ; Cobb, John ; Barton, Nicholas H ; Rolian, Campbell ; Chan, Yingguang Frank
Assuntos: Adaptation, Biological ; Animal experimentation ; Animals ; Beef ; Body mass ; Bone growth ; Breeding - methods ; Controlled conditions ; Developmental Biology ; Dysplasia ; Embryos ; Enhancers ; Evolution ; Evolution & development ; Evolution (Biology) ; Evolutionary Biology ; Experiments ; Extremities (Anatomy) ; Extremities - anatomy & histology ; Farmers ; Genes ; Genetic research ; Genomes ; Genomic analysis ; Genomics ; House mouse ; Laboratories ; limb development ; Mice ; Molecular genetics ; Physiological aspects ; population genetics ; Quantitative genetics ; selection experiment ; Selection, Genetic ; selective sweeps ; Surgery ; Whole Genome Sequencing
É parte de: eLife, 2019-06, Vol.8
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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These authors also contributed equally to this work.
Descrição: Evolutionary studies are often limited by missing data that are critical to understanding the history of selection. Selection experiments, which reproduce rapid evolution under controlled conditions, are excellent tools to study how genomes evolve under selection. Here we present a genomic dissection of the Longshanks selection experiment, in which mice were selectively bred over 20 generations for longer tibiae relative to body mass, resulting in 13% longer tibiae in two replicates. We synthesized evolutionary theory, genome sequences and molecular genetics to understand the selection response and found that it involved both polygenic adaptation and discrete loci of major effect, with the strongest loci tending to be selected in parallel between replicates. We show that selection may favor de-repression of bone growth through inactivating two limb enhancers of an inhibitor, . Our integrative genomic analyses thus show that it is possible to connect individual base-pair changes to the overall selection response.
Editor: England: eLife Science Publications, Ltd
Idioma: Inglês

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An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice

Castro, João Pl ; Yancoskie, Michelle N ; Marchini, Marta ; Belohlavy, Stefanie ; Hiramatsu, Layla ; Kučka, Marek ; Beluch, William H ; Naumann, Ronald ; Skuplik, Isabella ; Cobb, John ; Barton, Nicholas H ; Rolian, Campbell ; Chan, Yingguang Frank

England: eLife Science Publications, Ltd

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