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Cancer therapy with the viral and bacterial pathogens: The past enemies can be considered the present allies

Kiaheyrati, Niloofar ; Babaei, Abouzar ; Ranji, Reza ; Bahadoran, Ensiyeh ; Taheri, Shiva ; Farokhpour, Zahra

Life sciences (1973), 2024-07, Vol.349, p.122734, Article 122734 [Periódico revisado por pares]

Netherlands: Elsevier Inc

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  • Título:
    Cancer therapy with the viral and bacterial pathogens: The past enemies can be considered the present allies
  • Autor: Kiaheyrati, Niloofar ; Babaei, Abouzar ; Ranji, Reza ; Bahadoran, Ensiyeh ; Taheri, Shiva ; Farokhpour, Zahra
  • Assuntos: Animals ; Bacteria ; Bacteria-mediated cancer therapy ; Bacteriotherapy ; Cancer therapy ; Humans ; Neoplasms - immunology ; Neoplasms - therapy ; Oncolytic virotherapy ; Oncolytic Virotherapy - methods ; Oncolytic virus ; Oncolytic Viruses - physiology ; Tumor Microenvironment
  • É parte de: Life sciences (1973), 2024-07, Vol.349, p.122734, Article 122734
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    ObjectType-Review-3
    content type line 23
  • Descrição: Cancer continues to be one of the leading causes of mortality worldwide despite significant advancements in cancer treatment. Many difficulties have arisen as a result of the detrimental consequences of chemotherapy and radiotherapy as a common cancer therapy, such as drug inability to penetrate deep tumor tissue, and also the drug resistance in tumor cells continues to be a major concern. These obstacles have increased the need for the development of new techniques that are more selective and effective against cancer cells. Bacterial-based therapies and the use of oncolytic viruses can suppress cancer in comparison to other cancer medications. The tumor microenvironment is susceptible to bacterial accumulation and proliferation, which can trigger immune responses against the tumor. Oncolytic viruses (OVs) have also gained considerable attention in recent years because of their potential capability to selectively target and induce apoptosis in cancer cells. This review aims to provide a comprehensive summary of the latest literature on the role of bacteria and viruses in cancer treatment, discusses the limitations and challenges, outlines various strategies, summarizes recent preclinical and clinical trials, and emphasizes the importance of optimizing current strategies for better clinical outcomes. [Display omitted] •Oncolytic bacteria (OBs) and oncolytic viruses (OVs) are demonstrating potential as a novel approach to cancer therapy.•OVs selectively infect and destroy cancer cells, activating both innate and adaptive immune responses.•Endotoxins and other products of OBs have shown promise in tumor removal.•Bacteria can influence the immune response and enhance the effectiveness of OVs by producing therapeutic agents like cytokines or checkpoint inhibitors.
  • Editor: Netherlands: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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