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Epithelial-mesenchymal Plasticity in Breast Cancer Metastasis

T. Blick C. A. Pinto D. Huang A. Tachtsidis E. Widodo H. Hugo R. Wafai D. Gunasinghe I. Haviv M. E. Lenburg R. M. Neve D.F. Newgreen M.L. Ackland M. Waltham E. W. Thompson

Zhongguo fei ai za zhi, 2009, Vol.12 (6), p.I0001-I0002 [Periódico revisado por pares]

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Título:
Epithelial-mesenchymal Plasticity in Breast Cancer Metastasis
Autor: T. Blick C. A. Pinto D. Huang A. Tachtsidis E. Widodo H. Hugo R. Wafai D. Gunasinghe I. Haviv M. E. Lenburg R. M. Neve D.F. Newgreen M.L. Ackland M. Waltham E. W. Thompson
Assuntos: 治疗 ; 疗效 ; 癌细胞 ; 肺癌
É parte de: Zhongguo fei ai za zhi, 2009, Vol.12 (6), p.I0001-I0002
Notas: R734.2
12-1395/R
Descrição: Transitions between epithelial and mesenchymal states, which we have termed Epithelial Mesenchymal Plasticity （EMP）, are important for generation of the body plan during normal development. Epithehal-mesenchymal transition （EMT） allows for cells to dissociate from a cohesive epithelium and migrate/invade to another site. The reverse transition （MET） is required for the re-association of cells into a new functional unit. The molecular and cellular basis of these transitions is becoming more evident in carcinoma, where they have obvious parallels with metastatic spread. EMT has long been associated with breast cancer （BrCa） cell invasiveness in vitro and metastatic potential in vivo, and increasingly can be associated with clinical outcomes in BrCa.
Idioma: Chinês

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