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Toll-like receptor 4 in CNS pathologies

Buchanan, Madison M ; Hutchinson, Mark ; Watkins, Linda R ; Yin, Hang

Journal of neurochemistry, 2010-07, Vol.114 (1), p.13-27 [Periódico revisado por pares]

Oxford, UK: Oxford, UK : Blackwell Publishing Ltd

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Título:
Toll-like receptor 4 in CNS pathologies
Autor: Buchanan, Madison M ; Hutchinson, Mark ; Watkins, Linda R ; Yin, Hang
Assuntos: Alzheimer Disease - drug therapy ; Alzheimer Disease - immunology ; Alzheimer Disease - metabolism ; Animals ; Biological and medical sciences ; Brain ; Brain Ischemia - drug therapy ; Brain Ischemia - immunology ; Brain Ischemia - metabolism ; Cell receptors ; Cell structures and functions ; Central Nervous System Diseases - drug therapy ; Central Nervous System Diseases - immunology ; Central Nervous System Diseases - metabolism ; endogenous ligand ; Fundamental and applied biological sciences. Psychology ; glia ; Humans ; Immunity, Innate ; Inflammation - immunology ; Inflammation - metabolism ; Ischemia ; MD-2 ; Medical sciences ; Molecular and cellular biology ; Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine) ; Neoplasms - drug therapy ; Neoplasms - immunology ; Neoplasms - metabolism ; Neuroglia - physiology ; Neuroimmunomodulation ; neuroinflammation ; Neurology ; Neurons ; Pain - drug therapy ; Pain - immunology ; Pain - metabolism ; Pathology ; sepsis ; Sepsis - drug therapy ; Sepsis - immunology ; Sepsis - metabolism ; Signal Transduction ; Stroke - drug therapy ; Stroke - immunology ; Stroke - metabolism ; Synaptic Transmission ; Toll-like receptor ; Toll-Like Receptor 4 - agonists ; Toll-Like Receptor 4 - antagonists & inhibitors ; Toll-Like Receptor 4 - physiology ; Trauma ; Vascular diseases and vascular malformations of the nervous system
É parte de: Journal of neurochemistry, 2010-07, Vol.114 (1), p.13-27
Notas: http://dx.doi.org/10.1111/j.1471-4159.2010.06736.x
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Descrição: J. Neurochem. (2010) 114, 13-27. The responses of the brain to infection, ischemia and trauma share remarkable similarities. These and other conditions of the CNS coordinate an innate immune response marked by activation of microglia, the macrophage-like cells of the nervous system. An important contributor to microglial activation is toll-like receptor 4, a pathogen-associated molecular pattern receptor known to initiate an inflammatory cascade in response to various CNS stimuli. The present review traces new efforts to characterize and control toll-like receptor 4 in inflammatory etiologies of the nervous system.
Editor: Oxford, UK: Oxford, UK : Blackwell Publishing Ltd
Idioma: Inglês

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Toll-like receptor 4 in CNS pathologies

Buchanan, Madison M ; Hutchinson, Mark ; Watkins, Linda R ; Yin, Hang

Oxford, UK: Oxford, UK : Blackwell Publishing Ltd

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