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Mediators involved in the febrile response induced by Tityus serrulatus scorpion venom in rats

Pessini, Andréa C. ; Santos, Danielle R. ; Arantes, Eliane C. ; Souza, Glória E.P.

Toxicon (Oxford), 2006-10, Vol.48 (5), p.556-566 [Periódico revisado por pares]

Oxford: Elsevier Ltd

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Mediators involved in the febrile response induced by Tityus serrulatus scorpion venom in rats
Autor: Pessini, Andréa C. ; Santos, Danielle R. ; Arantes, Eliane C. ; Souza, Glória E.P.
Assuntos: Analgesics, Non-Narcotic - pharmacology ; Animal poisons toxicology. Antivenoms ; Animals ; Ascitic Fluid - chemistry ; Biological and medical sciences ; Body Temperature - drug effects ; Bradykinin - cerebrospinal fluid ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Fever ; Fever - chemically induced ; Fever - physiopathology ; IL-1 ; Indazoles - pharmacology ; Inflammation Mediators - pharmacology ; Inflammation Mediators - physiology ; Injections, Intraperitoneal ; Injections, Intravenous ; Interleukin-1 - pharmacology ; Male ; Medical sciences ; Neurotoxins - toxicity ; Rats ; Rats, Wistar ; Scorpion Venoms - toxicity ; Scorpions ; Telemetry ; Tityus serrulatus ; Tityus serrulatus venom ; Toxicology ; Vagotomy ; Vagus nerve
É parte de: Toxicon (Oxford), 2006-10, Vol.48 (5), p.556-566
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Tityus serrulatus venom (Tsv) was intraperitoneally (ip) injected at doses of 75, 150 and 300 μg/kg and IL-1 β (2.0 μg/kg) was given intravenously (iv) to male Wistar rats. Rectal temperature was measured by radiotelemetry. Vagotomy was performed according to Bluthe et al. [1994. Lipopolysaccharide induces sickness behaviour in rats by a vagal mediated mechanism. C R Acad. Sci. 317(6), 499–503]. Cerebrospinal fluid (CSF) and peritoneal fluid (PF) levels of bradykinin (BK) were measured by ELISA. B 1 (des-Arg 9-[Leu 8]-BK; DALBK) and B 2 kinin receptor (icatibant) antagonists (1.0 mg/kg each), the induced nitric oxide synthase inhibitor aminoguanidine (50.0 mg/kg), the neuronal nitric oxide synthase inhibitor 7-nitroindazole (30.0 mg/kg), the dual cyclooxygenase inhibitor ibuprofen (10.0 mg/kg), the selective interleukin-1 receptor antagonist IL-ra (2.0 mg/kg) and dipyrone (120 mg/kg) were given ip. Celecoxib (5 mg/kg) was given per os (po). Tsv at doses of 75 μg/kg evoked no change in rectal temperature while at doses of 150 and 300 μg/kg it promoted long-lasting fever (2 °C±0.1). Tsv (150 μg/kg) increased by nearly 3 and 5 times, respectively BK concentration in the CSF and in the PF. Subdiaphragmatic vagotomy or 7-nitroindazole reduced, icatibant, DALBK, IL-1ra, aminoguanidine and dipyrone abolished, while ibuprofen and celecoxib failed to affect Tsv-induced fever. These results suggest that PGs do not play a relevant role, whereas, kinins via their B 1 and B 2 receptors, IL-1, nitric oxide and vagal neurotransmission are involved in Tsv-induced fever.
Editor: Oxford: Elsevier Ltd
Idioma: Inglês

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Mediators involved in the febrile response induced by Tityus serrulatus scorpion venom in rats

Pessini, Andréa C. ; Santos, Danielle R. ; Arantes, Eliane C. ; Souza, Glória E.P.

Oxford: Elsevier Ltd

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