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Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids

Cyster, Jason G ; Pereira, João P ; An, Jinping ; Xu, Ying ; Huang, Yong

Nature immunology, 2009-04, Vol.10 (4), p.403-411 [Periódico revisado por pares]

United States: Nature Publishing Group

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Título:
Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids
Autor: Cyster, Jason G ; Pereira, João P ; An, Jinping ; Xu, Ying ; Huang, Yong
Assuntos: Animals ; B cells ; Bone marrow ; Bone Marrow - immunology ; Bone Marrow - physiology ; Cell Movement - physiology ; Cell receptors ; GTP-Binding Protein alpha Subunits - physiology ; Immunoglobulin lambda-Chains - blood ; Immunoglobulin lambda-Chains - immunology ; Integrin alpha4beta1 - immunology ; Integrin alpha4beta1 - physiology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Physiological aspects ; Precursor Cells, B-Lymphoid - cytology ; Precursor Cells, B-Lymphoid - immunology ; Precursor Cells, B-Lymphoid - physiology ; Receptor, Cannabinoid, CB2 - genetics ; Receptor, Cannabinoid, CB2 - immunology ; Receptor, Cannabinoid, CB2 - physiology ; Receptors, CXCR4 - immunology ; Receptors, CXCR4 - metabolism ; Spleen - immunology ; Up-Regulation ; Vascular Cell Adhesion Molecule-1 - immunology ; Vascular Cell Adhesion Molecule-1 - physiology
É parte de: Nature immunology, 2009-04, Vol.10 (4), p.403-411
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Immature B cells developing in the bone marrow are found in the parenchyma and sinusoids. The mechanisms that control the positioning of B cells in the sinusoids are not understood. Here we show that the integrin alpha(4)beta(1) (VLA-4) and its ligand VCAM-1 were required, whereas the chemokine receptor CXCR4 was dispensable, for sinusoidal retention of B cells. Instead, cannabinoid receptor 2 (CB2), a Galpha(i) protein-coupled receptor upregulated in immature B cells, was required for sinusoidal retention. Using two-photon microscopy, we found immature B cells entering and crawling in sinusoids; these immature B cells were displaced by CB2 antagonism. Moreover, CB2-deficient mice had a lower frequency of immunoglobulin lambda-chain-positive B cells in the peripheral blood and spleen. Our findings identify unique requirements for the retention of B cells in the bone marrow sinusoidal niche and suggest involvement of CB2 in the generation of the B cell repertoire.
Editor: United States: Nature Publishing Group
Idioma: Inglês

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Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids

Cyster, Jason G ; Pereira, João P ; An, Jinping ; Xu, Ying ; Huang, Yong

United States: Nature Publishing Group

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