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Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33

Houlston, Richard S ; Dunlop, Malcolm G ; Tomlinson, Ian P M ; Cheadle, Jeremy ; Dobbins, Sara E ; Tenesa, Albert ; Jones, Angela M ; Howarth, Kimberley ; Spain, Sarah L ; Broderick, Peter ; Domingo, Enric ; Farrington, Susan ; Prendergast, James G D ; Pittman, Alan M ; Theodoratou, Evi ; Smith, Christopher G ; Olver, Bianca ; Walther, Axel ; Barnetson, Rebecca A ; Churchman, Michael ; Jaeger, Emma E M ; Penegar, Steven ; Barclay, Ella ; Martin, Lynn ; Gorman, Maggie ; Mager, Rachel ; Johnstone, Elaine ; Midgley, Rachel ; Niittymäki, Iina ; Tuupanen, Sari ; Colley, James ; Idziaszczyk, Shelley ; Thomas, Huw J W ; Lucassen, Anneke M ; Evans, D Gareth R ; Maher, Eamonn R ; Maughan, Timothy ; Dimas, Antigone ; Dermitzakis, Emmanouil ; Cazier, Jean-Baptiste ; Aaltonen, Lauri A ; Pharoah, Paul ; Kerr, David J ; Carvajal-Carmona, Luis G ; Campbell, Harry

Nature genetics, 2010-11, Vol.42 (11), p.973-977 [Periódico revisado por pares]

New York, NY: Nature Publishing Group

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Título:
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33
Autor: Houlston, Richard S ; Dunlop, Malcolm G ; Tomlinson, Ian P M ; Cheadle, Jeremy ; Dobbins, Sara E ; Tenesa, Albert ; Jones, Angela M ; Howarth, Kimberley ; Spain, Sarah L ; Broderick, Peter ; Domingo, Enric ; Farrington, Susan ; Prendergast, James G D ; Pittman, Alan M ; Theodoratou, Evi ; Smith, Christopher G ; Olver, Bianca ; Walther, Axel ; Barnetson, Rebecca A ; Churchman, Michael ; Jaeger, Emma E M ; Penegar, Steven ; Barclay, Ella ; Martin, Lynn ; Gorman, Maggie ; Mager, Rachel ; Johnstone, Elaine ; Midgley, Rachel ; Niittymäki, Iina ; Tuupanen, Sari ; Colley, James ; Idziaszczyk, Shelley ; Thomas, Huw J W ; Lucassen, Anneke M ; Evans, D Gareth R ; Maher, Eamonn R ; Maughan, Timothy ; Dimas, Antigone ; Dermitzakis, Emmanouil ; Cazier, Jean-Baptiste ; Aaltonen, Lauri A ; Pharoah, Paul ; Kerr, David J ; Carvajal-Carmona, Luis G ; Campbell, Harry
Assuntos: Biological and medical sciences ; Cancer ; Chromosome Mapping - methods ; Chromosomes, Human, Pair 1 - genetics ; Chromosomes, Human, Pair 12 - genetics ; Chromosomes, Human, Pair 13 - genetics ; Chromosomes, Human, Pair 3 - genetics ; Classical genetics, quantitative genetics, hybrids ; Colorectal cancer ; Colorectal Neoplasms - genetics ; Data collection ; Disease susceptibility ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology. Liver. Pancreas. Abdomen ; Genetic aspects ; Genetic Predisposition to Disease ; Genetics of eukaryotes. Biological and molecular evolution ; Genome-Wide Association Study - methods ; Genotype ; Health aspects ; Humans ; Male ; Medical research ; Medical sciences ; Meta-analysis ; Meta-Analysis as Topic ; Methods, theories and miscellaneous ; Odds Ratio ; Oligonucleotide Array Sequence Analysis ; Polymorphism, Single Nucleotide ; Principal components analysis ; Quality control ; Risk Assessment ; Single nucleotide polymorphisms ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors
É parte de: Nature genetics, 2010-11, Vol.42 (11), p.973-977
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A full list of members is provided in the Supplementary Information
Descrição: Genome-wide association studies (GWAS) have identified ten loci harboring common variants that influence risk of developing colorectal cancer (CRC). To enhance the power to identify additional CRC risk loci, we conducted a meta-analysis of three GWAS from the UK which included a total of 3,334 affected individuals (cases) and 4,628 controls followed by multiple validation analyses including a total of 18,095 cases and 20,197 controls. We identified associations at four new CRC risk loci: 1q41 (rs6691170, odds ratio (OR) = 1.06, P = 9.55 × 10−10 and rs6687758, OR = 1.09, P = 2.27 × 10−9), 3q26.2 (rs10936599, OR = 0.93, P = 3.39 × 10−8), 12q13.13 (rs11169552, OR = 0.92, P = 1.89 × 10−10 and rs7136702, OR = 1.06, P = 4.02 × 10−8) and 20q13.33 (rs4925386, OR = 0.93, P = 1.89 × 10−10). In addition to identifying new CRC risk loci, this analysis provides evidence that additional CRC-associated variants of similar effect size remain to be discovered.
Editor: New York, NY: Nature Publishing Group
Idioma: Inglês

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Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33

New York, NY: Nature Publishing Group

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