Idioma:

Partial impairment of c-Ret at tyrosine 1062 accelerates age-related hearing loss in mice

Ohgami, Nobutaka ; Ida-Eto, Michiru ; Sakashita, Naomi ; Sone, Michihiko ; Nakashima, Tsutomu ; Tabuchi, Keiji ; Hoshino, Tomofumi ; Shimada, Atsuyoshi ; Tsuzuki, Toyonori ; Yamamoto, Masahiko ; Sobue, Gen ; Jijiwa, Mayumi ; Asai, Naoya ; Hara, Akira ; Takahashi, Masahide ; Kato, Masashi

Neurobiology of aging, 2012-03, Vol.33 (3), p.626.e25-626.e34 [Periódico revisado por pares]

United States: Elsevier Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Partial impairment of c-Ret at tyrosine 1062 accelerates age-related hearing loss in mice
Autor: Ohgami, Nobutaka ; Ida-Eto, Michiru ; Sakashita, Naomi ; Sone, Michihiko ; Nakashima, Tsutomu ; Tabuchi, Keiji ; Hoshino, Tomofumi ; Shimada, Atsuyoshi ; Tsuzuki, Toyonori ; Yamamoto, Masahiko ; Sobue, Gen ; Jijiwa, Mayumi ; Asai, Naoya ; Hara, Akira ; Takahashi, Masahide ; Kato, Masashi
Assuntos: Age-related deafness ; Animals ; c-Ret ; Disease Models, Animal ; Genetic Carrier Screening ; Internal Medicine ; Mice ; Mice, Inbred C57BL ; Mice, Neurologic Mutants ; Mutation ; Neurodegeneration ; Neurology ; Phenylalanine - genetics ; Phosphorylation - genetics ; Presbycusis - genetics ; Presbycusis - physiopathology ; Protein-Tyrosine Kinases - genetics ; Protein-Tyrosine Kinases - metabolism ; Proto-Oncogene Proteins c-ret - deficiency ; Proto-Oncogene Proteins c-ret - genetics ; Spiral Ganglion - metabolism ; Spiral Ganglion - pathology ; Spiral Ganglion - physiopathology ; Spiral ganglion neuron ; Tyrosine - genetics ; Tyrosine kinase ; Up-Regulation - genetics
É parte de: Neurobiology of aging, 2012-03, Vol.33 (3), p.626.e25-626.e34
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Article-2
ObjectType-Feature-1
Descrição: Abstract c-Ret has been shown to be crucial for neural development and survival. We have recently shown that complete impairment of tyrosine 1062 (Y1062)-phosphorylation in c-Ret causes congenital hearing loss with neurodegeneration of spiral ganglion neurons (SGNs) in homozygous c-Ret knockin mice ( c-Ret -KIY1062F/Y1062F -mice). However, there is no information to link c-Ret and age-related hearing loss. Here we show that partial impairment of Y1062-phosphorylation in c-Ret accelerates age-related hearing loss in heterozygous c-Ret Y1062F knockin mice ( c-Ret -KIY1062F/+ -mice). In contrast, complete impairment of serine 697 (S697)-phosphorylation in c-Ret did not affect hearing levels in 10-month-old homozygous c-Ret S697A knockin mice ( c-Ret -KIS697A/S697A -mice). The hearing loss involved late-onset neurodegeneration of spiral ganglion neurons in c-Ret -KIY1062F/+ -mice. Morphological abnormalities in inner- and outer-hair cells and the stria vascularis in c-Ret -KIY1062F/+ -mice were undetectable. The acceleration of age-related hearing loss in c-Ret -KIY1062F/+ -mice was rescued by introducing constitutively activated RET . Thus, our results suggest that c-Ret is a novel age-related hearing loss-related molecule in mice. Our results suggest that these hearing losses partially share a common pathogenesis that is monogenetically caused by a single point mutation (Y1062F) in c-Ret.
Editor: United States: Elsevier Inc
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Partial impairment of c-Ret at tyrosine 1062 accelerates age-related hearing loss in mice

Ohgami, Nobutaka ; Ida-Eto, Michiru ; Sakashita, Naomi ; Sone, Michihiko ; Nakashima, Tsutomu ; Tabuchi, Keiji ; Hoshino, Tomofumi ; Shimada, Atsuyoshi ; Tsuzuki, Toyonori ; Yamamoto, Masahiko ; Sobue, Gen ; Jijiwa, Mayumi ; Asai, Naoya ; Hara, Akira ; Takahashi, Masahide ; Kato, Masashi

United States: Elsevier Inc

Buscando em bases de dados remotas. Favor aguardar.