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IFN-γ plays an essential role in the pathogenesis of gastric lymphoid follicles formation caused by Helicobacter suis infection

Mimura, Takuya ; Yoshida, Masaru ; Nishiumi, Shin ; Tanaka, Hiroshi ; Nobutani, Kentaro ; Takenaka, Mamoru ; Suleiman, Yahaya Ben ; Yamamoto, Koji ; Ota, Hiroyoshi ; Takahashi, Shinichi ; Matsui, Hidenori ; Nakamura, Masahiko ; Miki, Ikuya ; Azuma, Takeshi

FEMS immunology and medical microbiology, 2011-10, Vol.63 (1), p.25-34 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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Título:
IFN-γ plays an essential role in the pathogenesis of gastric lymphoid follicles formation caused by Helicobacter suis infection
Autor: Mimura, Takuya ; Yoshida, Masaru ; Nishiumi, Shin ; Tanaka, Hiroshi ; Nobutani, Kentaro ; Takenaka, Mamoru ; Suleiman, Yahaya Ben ; Yamamoto, Koji ; Ota, Hiroyoshi ; Takahashi, Shinichi ; Matsui, Hidenori ; Nakamura, Masahiko ; Miki, Ikuya ; Azuma, Takeshi
Assuntos: Animals ; B-Lymphocytes - immunology ; Bacteriology ; Biological and medical sciences ; CD4 antigen ; Dendritic cells ; Dendritic Cells - immunology ; Follicles ; follicular gastritis ; Fundamental and applied biological sciences. Psychology ; gamma -Interferon ; Gastric mucosa ; Gastric Mucosa - immunology ; Gastric Mucosa - microbiology ; Gastric Mucosa - pathology ; Gene expression ; Gene Expression Profiling ; Helicobacter heilmannii - immunology ; Helicobacter heilmannii - pathogenicity ; Helicobacter suis ; Helper cells ; Histocytochemistry ; Immunohistochemistry ; Infection ; Infections ; Interferon ; Interferon-gamma - biosynthesis ; Interferon-gamma - deficiency ; Interferon-gamma - genetics ; Interferon-gamma - immunology ; Interferon‐γ ; Interleukin 4 ; Lymphocytes ; Lymphocytes B ; Lymphocytes T ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microbiology ; Microscopy ; Miscellaneous ; Pathogenesis ; RNA, Messenger - biosynthesis ; RNA, Messenger - genetics ; Rodents ; T-Lymphocytes, Helper-Inducer - immunology ; Time Factors ; γ-Interferon
É parte de: FEMS immunology and medical microbiology, 2011-10, Vol.63 (1), p.25-34
Notas: Editor: Nicholas Carbonetti
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Descrição: Abstract In this study, we aimed to assess the role of helper T cells in the development of gastric lymphoid follicles induced by Helicobacter suis infection. C57BL/6J mice were orally inoculated with H. suis. Six weeks after infection, gastric lymphoid follicles were observed in the gastric mucosa by hematoxylin and eosin staining, and the number of follicles was increased throughout the infection period. An immunohistological examination showed that the lymphoid follicles were composed of B cells, CD4-positive helper T cells, and dendritic cells (DC). It was also revealed that the mRNA expression level of interferon-γ (IFN-γ) in the gastric mucosa was significantly increased at 12 weeks after infection. No gastric lymphoid follicles were detected in IFN-γ-deficient mice that had been infected with H. suis at 12 weeks after infection, although the development of lymphoid follicles in IL-4-deficient mice infected with H. suis was similar to that seen in the wild-type mice. In conclusion, IFN-γ, a Th1 cytokine, is deeply involved in the pathogenesis of gastric lymphoid follicles induced by H. suis infection, and it is suggested that CD4-positive T cells and DC aid in the expansion of gastric lymphoid follicles.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

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IFN-γ plays an essential role in the pathogenesis of gastric lymphoid follicles formation caused by Helicobacter suis infection

Mimura, Takuya ; Yoshida, Masaru ; Nishiumi, Shin ; Tanaka, Hiroshi ; Nobutani, Kentaro ; Takenaka, Mamoru ; Suleiman, Yahaya Ben ; Yamamoto, Koji ; Ota, Hiroyoshi ; Takahashi, Shinichi ; Matsui, Hidenori ; Nakamura, Masahiko ; Miki, Ikuya ; Azuma, Takeshi

Oxford, UK: Blackwell Publishing Ltd

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