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Folate, Vitamin B6, and Vitamin B12 Intake and the Risk of Breast Cancer Among Mexican Women

Lajous, Martin ; Lazcano-Ponce, Eduardo ; Hernandez-Avila, Mauricio ; Willett, Walter ; Romieu, Isabelle

Cancer epidemiology, biomarkers & prevention, 2006-03, Vol.15 (3), p.443-448 [Periódico revisado por pares]

Philadelphia, PA: American Association for Cancer Research

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  • Título:
    Folate, Vitamin B6, and Vitamin B12 Intake and the Risk of Breast Cancer Among Mexican Women
  • Autor: Lajous, Martin ; Lazcano-Ponce, Eduardo ; Hernandez-Avila, Mauricio ; Willett, Walter ; Romieu, Isabelle
  • Assuntos: Biological and medical sciences ; Breast cancer ; diet ; folate ; Gynecology. Andrology. Obstetrics ; Mammary gland diseases ; Medical sciences ; Mexico ; nutrition ; Tropical medicine ; Tumors ; vitamin B
  • É parte de: Cancer epidemiology, biomarkers & prevention, 2006-03, Vol.15 (3), p.443-448
  • Descrição: Background: High intake of folate, vitamin B 6 , and vitamin B 12 have been hypothesized to lower the risk for breast cancer. We conducted a population-based case-control study to evaluate the risk for breast cancer among Mexican women with relatively low vitamin intakes. Methods: We included 475 women (median age, 53 years; range, 23-87 years) diagnosed with incident breast cancer through six hospitals in Mexico City and interviewed them to obtain data on breast cancer risk factors and their usual diet using a food frequency questionnaire. We selected 1,391 (median age, 49 years; range, 18-82 years) controls from the Mexico City population using a national sampling frame. Results: Compared with women in the lowest quartile, the odds ratio for breast cancer for women in the highest quartile of folate intake was 0.64 [95% confidence intervals (CI), 0.45-0.90; P , test for trend = 0.009] and 0.32 (95% CI, 0.22-0.49; P , test for trend < 0.0001) for vitamin B 12 intake. Among postmenopausal women, intakes of folate and vitamin B 12 were associated with a lower risk of breast cancer and those associations were stronger than among premenopausal women. The inverse association of folate and breast cancer was stronger among women who consumed a high level of vitamin B 12 as compared with women consuming diets low in vitamin B 12 . No association was observed for vitamin B 6 intake. Conclusions: In this population, high intakes of folate and vitamin B 12 were independently associated with decreased breast cancer risk, particularly among postmenopausal women. (Cancer Epidemiol Biomarkers Prev 2006;15(3):443–8)
  • Editor: Philadelphia, PA: American Association for Cancer Research
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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