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18F-Labeled NaF PET-CT in Detection of Bone Metastases in Patients With Preoperative Lung Cancer

Rao, Liangjun ; Zong, Zhen ; Chen, Zhifeng ; Wang, Xiaoyan ; Shi, Xinchong ; Yi, Chang ; Zhang, Xiangsong

Medicine (Baltimore), 2016-04, Vol.95 (16), p.e3490-e3490 [Periódico revisado por pares]

United States: Wolters Kluwer Health

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Título:
18F-Labeled NaF PET-CT in Detection of Bone Metastases in Patients With Preoperative Lung Cancer
Autor: Rao, Liangjun ; Zong, Zhen ; Chen, Zhifeng ; Wang, Xiaoyan ; Shi, Xinchong ; Yi, Chang ; Zhang, Xiangsong
Assuntos: Adult ; Aged ; Aged, 80 and over ; Bone Neoplasms - diagnosis ; Bone Neoplasms - secondary ; Diagnostic Accuracy Study ; Female ; Fluorodeoxyglucose F18 - pharmacology ; Humans ; Lung Neoplasms - diagnosis ; Lung Neoplasms - surgery ; Male ; Middle Aged ; Neoplasm Metastasis ; Pneumonectomy ; Positron-Emission Tomography - methods ; Preoperative Period ; Radiopharmaceuticals - pharmacology ; Reproducibility of Results ; Sodium Fluoride ; Tomography, Emission-Computed, Single-Photon ; Tomography, X-Ray Computed - methods ; Young Adult
É parte de: Medicine (Baltimore), 2016-04, Vol.95 (16), p.e3490-e3490
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: We compared the diagnostic accuracy of F-labeled sodium fluoride (F-NaF) PET-CT with 99m-technetium methylene diphosphonate (Tc-MDP) single photon emission computed tomography (SPECT) to detect bone metastases (BMs) in patients with preoperative lung cancer. Patients with lung cancer (n = 181) were examined with F-NaF PET-CT, and another 167 patients with lung cancer were examined with Tc-MDP SPECT. F-NaF PET-CT and Tc-MDP SPECT were evaluated by 2 experienced readers. Lesions were graded on a scale of 0 (degenerative lesion) to 4 (definite BM), and equivocal lesions were determined as indifferent (grade 3). Based on patient-based analysis, there were only 4 equivocal patients in F-NaF PET-CT detection. However, in Tc-MDP SPECT detection, there were 19 equivocal patients, which indicated a significant difference in terms of occurrence ratio (χ = 9.005, P = 0.03). Sensitivity and specificity of PET-CT was significantly better than that of SPECT when equivocal reading was categorized as malignant or benign (P < 0.05). Based on lesions-based analysis, SPECT produced 26 equivocal lesions of 333 lesions, but PET-CT produced only 5 equivocal lesions of 991 lesions. PET-CT was significantly better than SPECT in the aspect of producing equivocal patients (χ = 58.141, P < 0.001). Sensitivity and specificity of PET-CT was significantly better than that of SPECT when equivocal reading was categorized as malignant or benign (P < 0.05). F-NaF PET-CT is a highly sensitive and specific modality for the detection of BM in patients with preoperative lung cancer. It is better than conventional Tc-MDP SPECT in detecting BM in patients with preoperative lung cancer.
Editor: United States: Wolters Kluwer Health
Idioma: Inglês

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18F-Labeled NaF PET-CT in Detection of Bone Metastases in Patients With Preoperative Lung Cancer

Rao, Liangjun ; Zong, Zhen ; Chen, Zhifeng ; Wang, Xiaoyan ; Shi, Xinchong ; Yi, Chang ; Zhang, Xiangsong

United States: Wolters Kluwer Health

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