Idioma:

Leishmania amazonensis from distinct clinical forms/hosts has polymorphisms in Lipophosphoglycans, displays variations in immunomodulatory properties and, susceptibility to antileishmanial drugs

Rêgo, Felipe D. ; Cardoso, Camila d. A. ; Moreira, Paulo Otávio L. ; Nogueira, Paula M. ; Araújo, Márcio S. ; Borges, Valéria Matos ; Laurenti, Márcia D. ; Bartholomeu, Daniella C. ; Reis, Alexandre B. ; Monte‐Neto, Rubens L. d. ; Soares, Rodrigo P.

Cell biology international, 2022-11, Vol.46 (11), p.1947-1958 [Periódico revisado por pares]

England: Wiley Subscription Services, Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Leishmania amazonensis from distinct clinical forms/hosts has polymorphisms in Lipophosphoglycans, displays variations in immunomodulatory properties and, susceptibility to antileishmanial drugs
Autor: Rêgo, Felipe D. ; Cardoso, Camila d. A. ; Moreira, Paulo Otávio L. ; Nogueira, Paula M. ; Araújo, Márcio S. ; Borges, Valéria Matos ; Laurenti, Márcia D. ; Bartholomeu, Daniella C. ; Reis, Alexandre B. ; Monte‐Neto, Rubens L. d. ; Soares, Rodrigo P.
Assuntos: Amphotericin B ; Amphotericin B - pharmacology ; Animals ; Antileishmanial agents ; Dogs ; Glycoconjugates ; Glycosphingolipids ; Immune response ; Immunomodulation ; Immunosuppressive agents ; Inflammation ; Innate immunity ; Interleukin 6 ; Leishmania - genetics ; Leishmania amazonensis ; lipophosphoglycan ; Lipophosphoglycans ; macrophage ; Meglumine Antimoniate - pharmacology ; Mice ; Mice, Inbred BALB C ; Miltefosine ; Parasitic diseases ; Phosphorylcholine - analogs & derivatives ; Tumor Necrosis Factor-alpha ; Tumor necrosis factor-α ; Visceral leishmaniasis
É parte de: Cell biology international, 2022-11, Vol.46 (11), p.1947-1958
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Lipophosphoglycan (LPG), the major Leishmania glycoconjugate, induces pro‐inflammatory/immunosuppressive innate immune responses. Here, we evaluated functional/biochemical LPG properties from six Leishmania amazonensis strains from different hosts/clinical forms. LPGs from three strains (GV02, BA276, and LV79) had higher pro‐inflammatory profiles for most of the mediators, including tumor necrosis factor alpha and interleukin 6. For this reason, glycoconjugates from all strains were biochemically characterized and had polymorphisms in their repeat units. They consisted of three types: type I, repeat units devoid of side chains; type II, containing galactosylated side chains; and type III, containing glucosylated side chains. No relationship was observed between LPG type and the pro‐inflammatory properties. Finally, to evaluate the susceptibility against antileishmanial agents, two strains with high (GV02, BA276) and one with low (BA336) pro‐inflammatory activity were selected for chemotherapeutic tests in THP‐1 cells. All analyzed strains were susceptible to amphotericin B (AmB) but displayed various responses against miltefosine (MIL) and glucantime (GLU). The GV02 strain (canine visceral leishmaniasis) had the highest IC50 for MIL (3.34 μM), whereas diffuse leishmaniasis strains (BA276 and BA336) had a higher IC50 for GLU (6.87–12.19 mM). The highest IC50 against MIL shown by the GV02 strain has an impact on clinical management. Miltefosine is the only drug approved for dog treatment in Brazil. Further studies into drug susceptibility of L. amazonensis strains are warranted, especially in areas where dog infection by this species overlaps with those caused by Leishmania infantum.
Editor: England: Wiley Subscription Services, Inc
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 8 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Leishmania amazonensis from distinct clinical forms/hosts has polymorphisms in Lipophosphoglycans, displays variations in immunomodulatory properties and, susceptibility to antileishmanial drugs

Rêgo, Felipe D. ; Cardoso, Camila d. A. ; Moreira, Paulo Otávio L. ; Nogueira, Paula M. ; Araújo, Márcio S. ; Borges, Valéria Matos ; Laurenti, Márcia D. ; Bartholomeu, Daniella C. ; Reis, Alexandre B. ; Monte‐Neto, Rubens L. d. ; Soares, Rodrigo P.

England: Wiley Subscription Services, Inc

Buscando em bases de dados remotas. Favor aguardar.