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Human CD4+ Cytolytic T Lymphocyte Responses to a Human Immunodeficiency Virus Type 1 gp160 Subunit Vaccine

Stanhope, Patricia E. ; Clements, Mary Lou ; Siliciano, Robert F.

The Journal of infectious diseases, 1993-07, Vol.168 (1), p.92-100 [Periódico revisado por pares]

Chicago, IL: The University of Chicago Press

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Título:
Human CD4+ Cytolytic T Lymphocyte Responses to a Human Immunodeficiency Virus Type 1 gp160 Subunit Vaccine
Autor: Stanhope, Patricia E. ; Clements, Mary Lou ; Siliciano, Robert F.
Assuntos: AIDS Vaccines - immunology ; AIDS/HIV ; Antigens ; Biological and medical sciences ; CD4-Positive T-Lymphocytes - immunology ; Cell lines ; Clone Cells ; Cultured cells ; Gene Products, env - immunology ; HIV 1 ; HIV Envelope Protein gp160 ; HIV Infections - immunology ; HIV-1 - immunology ; Humans ; Immunization ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Longitudinal Studies ; Major Articles ; Medical sciences ; Phenotype ; Placebos ; Protein Precursors - immunology ; T lymphocytes ; T-Lymphocytes, Cytotoxic - immunology ; Vaccination ; Viruses ; Volunteerism
É parte de: The Journal of infectious diseases, 1993-07, Vol.168 (1), p.92-100
Notas: ark:/67375/HXZ-5W5R77D8-3
istex:34025A7F8D50033219F2FD548E184C4A586E095A
Reprints or correspondence: Dr. Robert Siliciano, Dept. of Medicine, Johns Hopkins University School of Medicine, 1049 Ross Bldg., 720 Rutland Ave., Baltimore, MD 21205.
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Descrição: The development of an effective vaccine against human immunodeficiency virus type 1 (HIV- 1) may require immunization protocols that elicit cytolytic T lymphocytes (CTL) in addition to neutralizing antibodies. This report demonstrates that vaccination of 4 HIV-L-seronegative volunteers with a recombinant HIV-1 gpI60 vaccine produced in mammalian cells elicited a CTL response in 3. The observed CTL activity was not mediated by classic CD8+ CTL but rather by cells of the CD4+ phenotype. The level of CTL activity varied over time, did not correlate with the proliferative response to gpI60, and was not increased by repeated immunization. At the clonal level, the vaccine was shown to elicit a functionally heterogeneous CD4+ T cell response that included clones with antigen-specific, major histocompatibility complex-restricted cytolytic activity. These clones were capable oflysing target cells expressing the HIV-1 env gene and thus might be active against HIV-1-infected cells in vivo.
Editor: Chicago, IL: The University of Chicago Press
Idioma: Inglês

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Human CD4+ Cytolytic T Lymphocyte Responses to a Human Immunodeficiency Virus Type 1 gp160 Subunit Vaccine

Stanhope, Patricia E. ; Clements, Mary Lou ; Siliciano, Robert F.

Chicago, IL: The University of Chicago Press

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