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Progestin and oestrogen receptors in meningiomas. Biochemical characterization, clinical and pathological correlations in 42 cases

Magdelenat, H ; Pertuiset, B F ; Poisson, M ; Martin, P M ; Philippon, J ; Pertuiset, B ; Buge, A

Acta neurochirurgica, 1982-01, Vol.64 (3-4), p.199-213 [Periódico revisado por pares]

Austria

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Título:
Progestin and oestrogen receptors in meningiomas. Biochemical characterization, clinical and pathological correlations in 42 cases
Autor: Magdelenat, H ; Pertuiset, B F ; Poisson, M ; Martin, P M ; Philippon, J ; Pertuiset, B ; Buge, A
Assuntos: Adult ; Aged ; Aldosterone - pharmacology ; Dexamethasone - pharmacology ; Female ; Humans ; Male ; Meningeal Neoplasms - analysis ; Meningeal Neoplasms - pathology ; Meningioma - analysis ; Meningioma - pathology ; Middle Aged ; Receptors, Estrogen - analysis ; Receptors, Estrogen - metabolism ; Receptors, Progesterone - analysis ; Receptors, Progesterone - metabolism
É parte de: Acta neurochirurgica, 1982-01, Vol.64 (3-4), p.199-213
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Progestin receptors (PR) were evaluated in 40 intracranial and 2 spinal meningiomas. PR measured with radiolabelled R 5020 were found in 93% of cases (39/42). PR levels were significantly higher (p = 0.05) in females (mean: 5,720 fmol/gmT) than in males (mean: 3,120 fmol/gmT). Biochemical characterization of the R 5020 saturable binding sites showed that they were mainly cytosolic, had a high affinity constant (Kd approximately equal to 1 nM) and were progestin specific. Correlation with sex suggested some biological activity of PR in meningiomas. Oestrogen receptors (OR) were evaluated in 36 intracranial and 2 spinal meningiomas. OR measured with radiolabelled R 2858 were present in 79% of cases (30/38). OR mean levels were equal in females (mean: 285 fmol/gmT) and in males (mean: 330 fmol/gmT). The relevance of PR and possibly OR in the biology of meningiomas and of leptomeninges was suggested by the presence of receptors in a sample of normal leptomeninges.
Editor: Austria
Idioma: Inglês

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Progestin and oestrogen receptors in meningiomas. Biochemical characterization, clinical and pathological correlations in 42 cases

Magdelenat, H ; Pertuiset, B F ; Poisson, M ; Martin, P M ; Philippon, J ; Pertuiset, B ; Buge, A

Austria

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