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Site-specific regulation of adult neurogenesis by dietary fatty acid content, vitamin E and flight exercise in European starlings

Hall, Zachary J. ; Bauchinger, Ulf ; Gerson, Alexander R. ; Price, Edwin R. ; Langlois, Lillie A. ; Boyles, Michelle ; Pierce, Barbara ; McWilliams, Scott R. ; Sherry, David F. ; MacDougall-Shackleton, Scott A.

The European journal of neuroscience, 2014-03, Vol.39 (6), p.875-882 [Periódico revisado por pares]

Oxford: Blackwell Publishing Ltd

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Título:
Site-specific regulation of adult neurogenesis by dietary fatty acid content, vitamin E and flight exercise in European starlings
Autor: Hall, Zachary J. ; Bauchinger, Ulf ; Gerson, Alexander R. ; Price, Edwin R. ; Langlois, Lillie A. ; Boyles, Michelle ; Pierce, Barbara ; McWilliams, Scott R. ; Sherry, David F. ; MacDougall-Shackleton, Scott A.
Assuntos: adult neurogenesis ; Animals ; Antioxidants ; Biological and medical sciences ; Birds ; Diet ; Dietary Fats - pharmacology ; Dietary supplements ; doublecortin ; European starling ; Fatty acid composition ; Fatty acids ; Fatty Acids - pharmacology ; Flight ; flight exercise ; Flight, Animal ; Fundamental and applied biological sciences. Psychology ; Male ; Neurogenesis ; Neuromodulation ; Nutrient deficiency ; Organ Specificity ; Physical Exertion ; Starlings - growth & development ; Starlings - physiology ; Sturnus vulgaris ; Telencephalon ; Telencephalon - drug effects ; Telencephalon - growth & development ; Therapeutic applications ; Vertebrates: nervous system and sense organs ; Vitamin E ; Vitamin E - pharmacology ; Vitamins - pharmacology ; Wind tunnels
É parte de: The European journal of neuroscience, 2014-03, Vol.39 (6), p.875-882
Notas: Table S1. Main and interaction effects of exercise, dietary fatty acid ratio and vitamin E on neuroanatomy in adult, male European starlings with significance values. In each cell, the top value is the F value and the lower number is the P value for each main or interaction effect.Table S2. Main and interaction effects of exercise, dietary fatty acid ratio and vitamin E on the number of fusiform and spherical doublecortin (DCX) neurons sampled in the brains of adult, male European starlings with significance values. In each cell, the top value is the F value and the lower number is the P value for each main or interaction effect.Table S3. Treatment assignment and brain measures for each European starling used in this study.
ArticleID:EJN12456
ark:/67375/WNG-Q6ZKT6SD-L
istex:C8ED03EBDBA93798FC5F593A9F4FCB263EB596D4
National Science Foundation of USA - No. IOS-0748349
Natural Sciences and Engineering Research Council of Canada - No. 217831
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Exercise is known to have a strong effect on neuroproliferation in mammals ranging from rodents to humans. Recent studies have also shown that fatty acids and other dietary supplements can cause an upregulation of neurogenesis. It is not known, however, how exercise and diet interact in their effects on adult neurogenesis. We examined neuronal recruitment in multiple telencephalic sites in adult male European starlings (Sturnus vulgaris) exposed to a factorial combination of flight exercise, dietary fatty acids and antioxidants. Experimental birds were flown in a wind tunnel following a training regime that mimicked the bird's natural flight behaviour. In addition to flight exercise, we manipulated the composition of dietary fatty acids and the level of enrichment with vitamin E, an antioxidant reported to enhance neuronal recruitment. We found that all three factors – flight exercise, fatty acid composition and vitamin E enrichment – regulate neuronal recruitment in a site‐specific manner. We also found a robust interaction between flight training and vitamin E enrichment at multiple sites of neuronal recruitment. Specifically, flight training was found to enhance neuronal recruitment across the telencephalon, but only in birds fed a diet with a low level of vitamin E. Conversely, dietary enrichment with vitamin E upregulated neuronal recruitment, but only in birds not flown in the wind tunnel. These findings indicate conserved modulation of adult neurogenesis by exercise and diet across vertebrate taxa and indicate possible therapeutic interventions in disorders characterized by reduced adult neurogenesis. Exercise and diet are known to have a strong effect on neuroproliferation in mammals ranging from rodents to humans. Here, we found that diet and exercise also upregulate neurogenesis, as measured using the immature neuronal marker doublecortin, in the adult avian brain.
Editor: Oxford: Blackwell Publishing Ltd
Idioma: Inglês

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Site-specific regulation of adult neurogenesis by dietary fatty acid content, vitamin E and flight exercise in European starlings

Hall, Zachary J. ; Bauchinger, Ulf ; Gerson, Alexander R. ; Price, Edwin R. ; Langlois, Lillie A. ; Boyles, Michelle ; Pierce, Barbara ; McWilliams, Scott R. ; Sherry, David F. ; MacDougall-Shackleton, Scott A.

Oxford: Blackwell Publishing Ltd

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