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Sodium intake in infancy and blood pressure at 7 years: findings from the Avon Longitudinal Study of Parents and Children

Brion, M.J ; Ness, A.R ; Davey Smith, G ; Emmett, P ; Rogers, I ; Whincup, P ; Lawlor, D.A

European journal of clinical nutrition, 2008-10, Vol.62 (10), p.1162-1169 [Periódico revisado por pares]

Basingstoke: Nature Publishing

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Sodium intake in infancy and blood pressure at 7 years: findings from the Avon Longitudinal Study of Parents and Children
Autor: Brion, M.J ; Ness, A.R ; Davey Smith, G ; Emmett, P ; Rogers, I ; Whincup, P ; Lawlor, D.A
Assuntos: age ; Aging - physiology ; Avon Longitudinal Study of Parents and Children ; Babies ; Biological and medical sciences ; Blood pressure ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Breast feeding ; Child ; Children ; Cohort Studies ; Correlation analysis ; Critical period ; Diastole ; Diet ; England ; Feeding. Feeding behavior ; Female ; Food and nutrition ; Fundamental and applied biological sciences. Psychology ; Health aspects ; Humans ; Infant ; infant formulas ; infant nutrition ; Infant Nutritional Physiological Phenomena - physiology ; Infants ; Longitudinal studies ; Male ; Medical sciences ; Metabolic diseases ; neonates ; Nutrition Policy ; Parents ; Potassium ; Potassium, Dietary - administration & dosage ; Potassium, Dietary - adverse effects ; Prospective Studies ; school children ; Sodium ; sodium intake ; Sodium salts ; Sodium, Dietary - administration & dosage ; Sodium, Dietary - adverse effects ; Systole ; systolic blood pressure ; temporal variation ; Time Factors ; Vertebrates: anatomy and physiology, studies on body, several organs or systems
É parte de: European journal of clinical nutrition, 2008-10, Vol.62 (10), p.1162-1169
Notas: http://dx.doi.org/10.1038/sj.ejcn.1602837
Descrição: Background: Infancy may be a sensitive period regarding effects of sodium intake on future blood pressure (BP). This has only been demonstrated in one randomized trial of low sodium formulae with follow-up in adolescence in one-third of participants. Objective: To prospectively assess associations between sodium intake in infancy and BP at 7 years in the Avon Longitudinal Study of Parents and Children (ALSPAC). Subjects: A total of 533 children with sodium data at 4 months and 710 children with sodium at 8 months. Results: 0.4% of participants at 4 months and 73.0% at 8 months exceeded recommended levels for infant sodium intake. After minimal adjustment (child age, sex, energy), sodium intake at 4 months was positively associated with systolic blood pressure (SBP) at 7 years (β=0.54 mm Hg/mmol; 95% CI: 0.09, 0.98 mm Hg; P=0.02). This changed little following adjustment for confounders but attenuated after adjusting for breastfeeding. This association was not mediated by sodium intake at 7 years. Due to high sodium-potassium correlations, effects of sodium independent of potassium could not be estimated with reasonable precision. Sodium intake neither at 8 months nor at 7 years was associated with SBP at 7 years. Conclusion: The association between sodium intake at 4 months and future SBP requires replication in studies that can control for effects of potassium before we can conclude that early infancy is a sensitive period with respect to effects of sodium on future BP. The majority of infants exceeded recommended levels of sodium intake at 8 months, and interventions to reduce sodium in infants' diets should be considered.
Editor: Basingstoke: Nature Publishing
Idioma: Inglês

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Sodium intake in infancy and blood pressure at 7 years: findings from the Avon Longitudinal Study of Parents and Children

Brion, M.J ; Ness, A.R ; Davey Smith, G ; Emmett, P ; Rogers, I ; Whincup, P ; Lawlor, D.A

Basingstoke: Nature Publishing

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