Idioma:

The Contribution of Visceral Adipose Tissue to Splanchnic Cortisol Production in Healthy Humans

ANDREW, Ruth ; WESTERBACKA, Jukka ; WAHREN, John ; YKI-JÄRVINEN, Hannele ; WALKER, Brian R

Diabetes (New York, N.Y.), 2005-05, Vol.54 (5), p.1364-1370 [Periódico revisado por pares]

Alexandria, VA: American Diabetes Association

Texto completo disponível

Citações Citado por

Enviar para

Título:
The Contribution of Visceral Adipose Tissue to Splanchnic Cortisol Production in Healthy Humans
Autor: ANDREW, Ruth ; WESTERBACKA, Jukka ; WAHREN, John ; YKI-JÄRVINEN, Hannele ; WALKER, Brian R
Assuntos: 11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism ; Adipose tissue ; Adipose Tissue - physiology ; Adipose tissues ; Adult ; Biological and medical sciences ; Body fat ; Corticosteroids ; Dehydrogenases ; Diabetes ; Diabetes mellitus ; Diabetes. Impaired glucose tolerance ; Diagnosis ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Enzymes ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Genetic aspects ; Glucocorticoids ; Hepatitis ; Hormones ; Humans ; Hydrocortisone - biosynthesis ; Hydrocortisone - blood ; Hydrocortisone - pharmacology ; Hyperglycemia ; Hypertension ; Infusions, Intravenous ; Insulin resistance ; Insulin Resistance - physiology ; Kinetics ; Liver ; Liver - metabolism ; Male ; Medical sciences ; Medicin och hälsovetenskap ; Metabolic disorders ; Metabolites ; Obesity ; Reference Values ; Splanchnic Circulation - physiology ; Veins & arteries ; Viscera - metabolism
É parte de: Diabetes (New York, N.Y.), 2005-05, Vol.54 (5), p.1364-1370
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The Contribution of Visceral Adipose Tissue to Splanchnic Cortisol Production in Healthy Humans Ruth Andrew 1 , Jukka Westerbacka 2 , John Wahren 3 , Hannele Yki-Järvinen 2 and Brian R. Walker 1 1 Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, U.K 2 Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland 3 Department of Surgical Sciences, Division of Clinical Physiology, Karolinska Hospital, Stockholm, Sweden Address correspondence and reprint requests to Professor Brian R. Walker, Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, U.K. E-mail: b.walker{at}ed.ac.uk Abstract Cortisol is regenerated from cortisone by 11β-hydroxysteroid dehydrogenase type 1 (11HSD1), amplifying glucocorticoid action in adipose tissue and liver. 11HSD1 inhibitors are being developed for type 2 diabetes and may be most effective in obesity, where adipose 11HSD1 is increased. However, the magnitude of regeneration of cortisol in different tissues in humans is unknown, hindering understanding of the pathophysiological and therapeutic importance of 11HSD1. In eight healthy men, we infused 9,11,12,12- 2 H 4 -cortisol and measured tracer enrichment in the hepatic vein as an indicator of total splanchnic cortisol generation. Oral cortisone (25 mg) was then given to measure first-pass hepatic cortisol generation. In steady state, splanchnic cortisol production was 45 ± 11 nmol/min when arterialized plasma cortisone concentration was 92 ± 7 nmol/l. Extrapolation from hepatic cortisol generation after oral corti-sone suggested that, at steady state, the liver contributes 15.2 nmol/min and extrahepatic splanchnic tissue contributes 29.8 nmol/min to the total splanchnic cortisol production. We conclude that tissues draining into the portal vein, including visceral adipose tissue, contribute substantially to the regeneration of cortisol. Thus, in addition to free fatty acids and adipokines, the portal vein delivers cortisol to the liver, and inhibition of 11HSD1 in visceral adipose tissue may indeed be valuable in ameliorating insulin resistance in obesity. 11HSD1, 11β-hydroxysteroid dehydrogenase type 1 ICG, indocyanin green TTR, tracer-to-tracee ratio Footnotes R.A. and J.W. contributed equally to this study. Accepted January 27, 2005. Received December 16, 2004. DIABETES
Editor: Alexandria, VA: American Diabetes Association
Idioma: Inglês

Links

Voltar para lista de resultados

Anterior Resultado 9 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

The Contribution of Visceral Adipose Tissue to Splanchnic Cortisol Production in Healthy Humans

ANDREW, Ruth ; WESTERBACKA, Jukka ; WAHREN, John ; YKI-JÄRVINEN, Hannele ; WALKER, Brian R

Alexandria, VA: American Diabetes Association

Buscando em bases de dados remotas. Favor aguardar.