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Biological markers changes at the very early stage of ageing (60-65 years). Is there a gender-related effect?

Daniela Teixeira Mayari E Ishimura; Ieda M Longo-Maugeri; Maria Lúcia Lebrão; Yeda Aparecida de Oliveira Duarte; Valquiria Bueno

Journal of Aging Science Los Angeles, CA v. 3, n. 1, 2015

Los Angeles, CA 2015

Acesso online. A biblioteca também possui exemplares impressos.

  • Título:
    Biological markers changes at the very early stage of ageing (60-65 years). Is there a gender-related effect?
  • Autor: Daniela Teixeira
  • Mayari E Ishimura; Ieda M Longo-Maugeri; Maria Lúcia Lebrão; Yeda Aparecida de Oliveira Duarte; Valquiria Bueno
  • Assuntos: ENVELHECIMENTO; SISTEMA IMUNE; LINFÓCITOS
  • É parte de: Journal of Aging Science Los Angeles, CA v. 3, n. 1, 2015
  • Notas: Disponível em: < http://www.esciencecentral.org/journals/biological-markers-changes-at-the-very-early-stage-of-ageing-6065-years-isthere-a-genderrelated-effect-2329-8847-1000132.pdf >. Acesso em: 02 jun. 2016.
  • Descrição: Ageing has been associated with progressive molecular and structural changes causing loss of function in several organs. There is a general hypothesis that very old individuals suffer profound modifications where different domains (immune, metabolic and cognitive) loose the tight functional interconnection present in younger bodies. However, it is not clear how this interconnection is affected at the very early stage of ageing and whether gender plays a role. Therefore, our aim was to evaluate some biological markers in non-institutionalized “healthy individuals” at the very early stage of ageing (60 to 65 years old, female and male). Blood was collected and serum creatinine, albumin and glucose were measured. In addition, we evaluated these individuals for lymphocytes phenotype (T CD4+, T CD8+, CD19+) by flow cytometry in peripheral mononuclear blood cells. It was observed that at the early stage of ageing male present higher creatinine and albumin serum levels compared to female. In addition, male had higher percentages of effector memory CD4+ and CD8+ T cells and lower percentages of naive CD8+ T cells. No differences were observed for B cells. These findings suggest that metabolic functions and immune system are compromised in male individuals at the very early stage of ageing. Functional studies in lymphocytes and oxidative stress in erythrocytes are required to confirm our hypothesis and in case of positive association gender differences should be considered for vaccination strategies and development of new therapies.
  • Editor: Los Angeles, CA
  • Data de criação/publicação: 2015
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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