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A lysosomal proton pump turns on when glucose runs out

Parra, Karlett J. ; Hayek, Summer R.

The Journal of biological chemistry, 2018-06, Vol.293 (23), p.9124-9125 [Periódico revisado por pares]

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Título:
A lysosomal proton pump turns on when glucose runs out
Autor: Parra, Karlett J. ; Hayek, Summer R.
Assuntos: AMP-Activated Protein Kinases - metabolism ; Animals ; Editors' Picks Highlights ; Glucose - metabolism ; Humans ; Proto-Oncogene Proteins c-akt - metabolism ; Saccharomyces cerevisiae - metabolism ; Saccharomyces cerevisiae Proteins - metabolism ; Signal Transduction ; Vacuolar Proton-Translocating ATPases - metabolism
É parte de: The Journal of biological chemistry, 2018-06, Vol.293 (23), p.9124-9125
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Edited by Alex Toker
Descrição: Vacuolar H+-ATPase (V-ATPase) is a glucose-responsive, ATP-driven proton pump that controls the acidity of cellular organelles. Increases in glucose stimulate V-ATPase assembly and activity, and glucose deprivation triggers rapid V-ATPase disassembly and inactivation in yeast. McGuire and Forgac describe the opposite phenomenon in mammalian cells, specifically that V-ATPase assembly and activation increases when glucose is lost, raising new questions about mammalian mechanisms of energy conservation.
Editor: United States: Elsevier Inc
Idioma: Inglês

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