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Warfarin Response and Vitamin K Epoxide Reductase Complex 1 in African Americans and Caucasians

Schelleman, H ; Chen, Z ; Kealey, C ; Whitehead, A S ; Christie, J ; Price, M ; Brensinger, C M ; Newcomb, C W ; Thorn, C F ; Samaha, F F ; Kimmel, S E

Clinical pharmacology and therapeutics, 2007-05, Vol.81 (5), p.742-747 [Periódico revisado por pares]

New York, NY: Nature Publishing

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Warfarin Response and Vitamin K Epoxide Reductase Complex 1 in African Americans and Caucasians
Autor: Schelleman, H ; Chen, Z ; Kealey, C ; Whitehead, A S ; Christie, J ; Price, M ; Brensinger, C M ; Newcomb, C W ; Thorn, C F ; Samaha, F F ; Kimmel, S E
Assuntos: African Americans - genetics ; Aged ; Anticoagulants - administration & dosage ; Anticoagulants - pharmacology ; Apolipoproteins E - genetics ; Aryl Hydrocarbon Hydroxylases - genetics ; Aryl Hydrocarbon Hydroxylases - metabolism ; Biological and medical sciences ; Cohort Studies ; Confidence Intervals ; Cytochrome P-450 CYP2C9 ; DNA - genetics ; European Continental Ancestry Group - genetics ; Female ; Humans ; International Normalized Ratio ; Male ; Medical sciences ; Middle Aged ; Mixed Function Oxygenases - genetics ; Odds Ratio ; Pharmacology. Drug treatments ; Polymorphism, Genetic - genetics ; Prospective Studies ; Reverse Transcriptase Polymerase Chain Reaction ; Treatment Outcome ; Vitamin K Epoxide Reductases ; Warfarin - administration & dosage ; Warfarin - pharmacology
É parte de: Clinical pharmacology and therapeutics, 2007-05, Vol.81 (5), p.742-747
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SourceType-Scholarly Journals-1
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Descrição: The objective of this study was to determine whether two vitamin K epoxide reductase complex 1 (VKORC1) polymorphisms contribute to the variability in warfarin response, particularly in African Americans. The effect of the VKORC1 1173C/T and −1639G/A polymorphisms was examined in a prospective cohort study of 338 warfarin users. Subjects carrying an 1173T allele had a lower warfarin maintenance dose compared with subjects with the CC genotype in African Americans (−12.10 mg/week±4.93; P=0.02) and Caucasians (−14.41 mg/week±3.28; P<0.001). Before reaching maintenance dose, only Caucasians with the T allele had significantly increased risk of international normalized ratio >3 (odds ratio=3.10; 95% confidence interval: 1.73–5.55) compared with Caucasians with the CC genotype. Polymorphisms in the VKORC1 gene are associated with warfarin maintenance dose requirements among both African Americans and Caucasians. However, these polymorphisms may not be as useful in predicting over‐anticoagulation among African Americans. Clinical Pharmacology & Therapeutics (2007) 81, 742–747. doi:10.1038/sj.clpt.6100144; published online 28 February 2007.
Editor: New York, NY: Nature Publishing
Idioma: Inglês

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Warfarin Response and Vitamin K Epoxide Reductase Complex 1 in African Americans and Caucasians

Schelleman, H ; Chen, Z ; Kealey, C ; Whitehead, A S ; Christie, J ; Price, M ; Brensinger, C M ; Newcomb, C W ; Thorn, C F ; Samaha, F F ; Kimmel, S E

New York, NY: Nature Publishing

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