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Newly Discovered Mycobacterial Pathogen Isolated from Laboratory Colonies of Xenopus Species with Lethal Infections Produces a Novel Form of Mycolactone, the Mycobacterium ulcerans Macrolide Toxin

Mve-Obiang, Armand ; Lee, Richard E ; Umstot, Edward S ; Trott, Kristin A ; Grammer, Timothy C ; Parker, John M ; Ranger, Brian S ; Grainger, Robert ; Mahrous, Engu A ; Small, P. L. C

Infection and Immunity, 2005-06, Vol.73 (6), p.3307-3312 [Periódico revisado por pares]

Washington, DC: American Society for Microbiology

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Título:
Newly Discovered Mycobacterial Pathogen Isolated from Laboratory Colonies of Xenopus Species with Lethal Infections Produces a Novel Form of Mycolactone, the Mycobacterium ulcerans Macrolide Toxin
Autor: Mve-Obiang, Armand ; Lee, Richard E ; Umstot, Edward S ; Trott, Kristin A ; Grammer, Timothy C ; Parker, John M ; Ranger, Brian S ; Grainger, Robert ; Mahrous, Engu A ; Small, P. L. C
Assuntos: Animals ; Antigens, Bacterial - genetics ; Bacterial Proteins ; Bacterial Toxins - chemistry ; Bacterial Toxins - genetics ; Bacterial Toxins - isolation & purification ; Base Sequence ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Macrolides ; Mice ; Microbiology ; Molecular Pathogenesis ; Molecular Sequence Data ; Mycobacterium liflandii ; Mycobacterium marinum ; Mycobacterium ulcerans ; Mycobacterium ulcerans - pathogenicity ; Nontuberculous Mycobacteria - pathogenicity ; Peptide Fragments - genetics ; Virulence ; Xenopus - microbiology ; Xenopus tropicalis
É parte de: Infection and Immunity, 2005-06, Vol.73 (6), p.3307-3312
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Editor: J. T. Barbieri
Corresponding author. Mailing address: Department of Microbiology, 409 Walters Life Sciences, University of Tennessee, Knoxville, TN 37996-0845. Phone: (865) 974-4042. Fax: (865)974-4007. E-mail: psmall@utk.edu.
Descrição: Mycobacterium ulcerans, the causative agent of Buruli ulcer, produces a macrolide toxin, mycolactone A/B, which is thought to play a major role in virulence. A disease similar to Buruli ulcer recently appeared in United States frog colonies following importation of the West African frog, Xenopus tropicalis. The taxonomic position of the frog pathogen has not been fully elucidated, but this organism, tentatively designated Mycobacterium liflandii, is closely related to M. ulcerans and Mycobacterium marinum, and as further evidence is gathered, it will most likely be considered a subspecies of one of these species. In this paper we show that M. liflandii produces a novel plasmid-encoded mycolactone, mycolactone E. M. liflandii contains all of the genes in the mycolactone cluster with the exception of that encoding CYP140A2, a putative p450 monooxygenase. Although the core lactone structure is conserved in mycolactone E, the fatty acid side chain differs from that of mycolactone A/B in the number of hydroxyl groups and double bonds. The cytopathic phenotype of mycolactone E is identical to that of mycolactone A/B, although it is less potent. To further characterize the relationship between M. liflandii and M. ulcerans, strains were analyzed for the presence of the RD1 region genes, esxA (ESAT-6) and esxB (CFP-10). The M. ulcerans genome strain has a deletion in RD1 and lacks these genes. The results of these studies show that M. liflandii contains both esxA and esxB.
Editor: Washington, DC: American Society for Microbiology
Idioma: Inglês

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Newly Discovered Mycobacterial Pathogen Isolated from Laboratory Colonies of Xenopus Species with Lethal Infections Produces a Novel Form of Mycolactone, the Mycobacterium ulcerans Macrolide Toxin

Mve-Obiang, Armand ; Lee, Richard E ; Umstot, Edward S ; Trott, Kristin A ; Grammer, Timothy C ; Parker, John M ; Ranger, Brian S ; Grainger, Robert ; Mahrous, Engu A ; Small, P. L. C

Washington, DC: American Society for Microbiology

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