Language:

Genomic analysis and clinical correlations of non-small cell lung cancer brain metastasis

Skakodub, Anna ; Walch, Henry ; Tringale, Kathryn R ; Eichholz, Jordan ; Imber, Brandon S ; Vasudevan, Harish N ; Li, Bob T ; Moss, Nelson S ; Hei Yu, Kenny Kwok ; Mueller, Boris A ; Powell, Simon ; Razavi, Pedram ; Yu, Helena A ; Reis-Filho, Jorge S ; Gomez, Daniel ; Schultz, Nikolaus ; Pike, Luke R G

Nature communications, 2023-08, Vol.14 (1), p.4980-4980, Article 4980 [Peer Reviewed Journal]

England: Nature Publishing Group

Full text available

Citations Cited by

Actions
1. Add to e-Shelf
2. Remove from e-Shelf
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Genomic analysis and clinical correlations of non-small cell lung cancer brain metastasis
Author: Skakodub, Anna ; Walch, Henry ; Tringale, Kathryn R ; Eichholz, Jordan ; Imber, Brandon S ; Vasudevan, Harish N ; Li, Bob T ; Moss, Nelson S ; Hei Yu, Kenny Kwok ; Mueller, Boris A ; Powell, Simon ; Razavi, Pedram ; Yu, Helena A ; Reis-Filho, Jorge S ; Gomez, Daniel ; Schultz, Nikolaus ; Pike, Luke R G
Subjects: Brain ; Brain cancer ; Brain Neoplasms - genetics ; Carcinoma, Non-Small-Cell Lung - genetics ; Cell cycle ; Epidermal growth factor receptors ; ErbB Receptors - genetics ; Genomic analysis ; Genomics ; Humans ; Lung cancer ; Lung Neoplasms - genetics ; Meninges ; Metastases ; Metastasis ; Myc protein ; Non-small cell lung carcinoma ; Regional development ; Small cell lung carcinoma ; Tumors
Is Part Of: Nature communications, 2023-08, Vol.14 (1), p.4980-4980, Article 4980
Notes: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Description: Up to 50% of patients with non-small cell lung cancer (NSCLC) develop brain metastasis (BM), yet the study of BM genomics has been limited by tissue access, incomplete clinical data, and a lack of comparison with paired extracranial specimens. Here we report a cohort of 233 patients with resected and sequenced (MSK-IMPACT) NSCLC BM and comprehensive clinical data. With matched samples (47 primary tumor, 42 extracranial metastatic), we show CDKN2A/B deletions and cell cycle pathway alterations to be enriched in the BM samples. Meaningful clinico-genomic correlations are noted, namely EGFR alterations in leptomeningeal disease (LMD) and MYC amplifications in multifocal regional brain progression. Patients who developed early LMD frequently have had uncommon, multiple, and persistently detectable EGFR driver mutations. The distinct mutational patterns identified in BM specimens compared to other tissue sites suggest specific biologic underpinnings of intracranial progression.
Publisher: England: Nature Publishing Group
Language: English

Links

View this record in MEDLINE/PubMed

Back to results list

Previous Result 2 Next Go to Next page

Implemented by: Social Network Logos:

Genomic analysis and clinical correlations of non-small cell lung cancer brain metastasis

England: Nature Publishing Group

Searching Remote Databases, Please Wait