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Human, Nonhuman Primate, and Bat Cells Are Broadly Susceptible to Tibrovirus Particle Cell Entry

Caì, Yíngyún ; Yú, Shuǐqìng ; Jangra, Rohit K ; Postnikova, Elena N ; Wada, Jiro ; Tesh, Robert B ; Whelan, Sean P J ; Lauck, Michael ; Wiley, Michael R ; Finch, Courtney L ; Radoshitzky, Sheli R ; O'Connor, David H ; Palacios, Gustavo ; Chandran, Kartik ; Chiu, Charles Y ; Kuhn, Jens H

Frontiers in microbiology, 2019-04, Vol.10, p.856 [Periódico revisado por pares]

Switzerland: Frontiers Media S.A

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  • Título:
    Human, Nonhuman Primate, and Bat Cells Are Broadly Susceptible to Tibrovirus Particle Cell Entry
  • Autor: Caì, Yíngyún ; Yú, Shuǐqìng ; Jangra, Rohit K ; Postnikova, Elena N ; Wada, Jiro ; Tesh, Robert B ; Whelan, Sean P J ; Lauck, Michael ; Wiley, Michael R ; Finch, Courtney L ; Radoshitzky, Sheli R ; O'Connor, David H ; Palacios, Gustavo ; Chandran, Kartik ; Chiu, Charles Y ; Kuhn, Jens H
  • Assuntos: Bas-Congo virus ; Microbiology ; Mononegavirales ; mononegavirus ; Rhabdoviridae ; rhabdovirus ; tibrovirus
  • É parte de: Frontiers in microbiology, 2019-04, Vol.10, p.856
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Edited by: Daniel Roberto Perez, University of Georgia, United States
    Reviewed by: Gary Whittaker, Cornell University, United States; Keita Matsuno, Hokkaido University, Japan
    These authors have contributed equally to this work
    This article was submitted to Virology, a section of the journal Frontiers in Microbiology
  • Descrição: In 2012, the genome of a novel rhabdovirus, Bas-Congo virus (BASV), was discovered in the acute-phase serum of a Congolese patient with presumed viral hemorrhagic fever. In the absence of a replicating virus isolate, fulfilling Koch's postulates to determine whether BASV is indeed a human virus and/or pathogen has been impossible. However, experiments with vesiculoviral particles pseudotyped with Bas-Congo glycoprotein suggested that BASV particles can enter cells from multiple animals, including humans. In 2015, genomes of two related viruses, Ekpoma virus 1 (EKV-1) and Ekpoma virus 2 (EKV-2), were detected in human sera in Nigeria. Isolates could not be obtained. Phylogenetic analyses led to the classification of BASV, EKV-1, and EKV-2 in the same genus, , together with five biting midge-borne rhabdoviruses [i.e., Beatrice Hill virus (BHV), Bivens Arm virus (BAV), Coastal Plains virus (CPV), Sweetwater Branch virus (SWBV), and Tibrogargan virus (TIBV)] not known to infect humans. Using individual recombinant vesiculoviruses expressing the glycoproteins of all eight known tibroviruses and more than 75 cell lines representing different animal species, we demonstrate that the glycoproteins of all tibroviruses can mediate vesiculovirus particle entry into human, bat, nonhuman primate, cotton rat, boa constrictor, and Asian tiger mosquito cells. Using four of five isolated authentic tibroviruses (i.e., BAV, CPV, SWBV, and TIBV), our experiments indicate that many cell types may be partially resistant to tibrovirus replication after virion cell entry. Consequently, experimental data solely obtained from experiments using tibrovirus surrogate systems (e.g., vesiculoviral pseudotypes, recombinant vesiculoviruses) cannot be used to predict whether BASV, or any other tibrovirus, infects humans.
  • Editor: Switzerland: Frontiers Media S.A
  • Idioma: Inglês
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