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Medial Prefrontal Cortex Lesions in the Female Rat Affect Sexual and Maternal Behavior and Their Sequential Organization

Afonso, Veronica M ; Sison, Margarette ; Lovic, Vedran ; Fleming, Alison S Disterhoft, John F

Behavioral neuroscience, 2007-06, Vol.121 (3), p.515-526 [Periódico revisado por pares]

Washington, DC: American Psychological Association

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Título:
Medial Prefrontal Cortex Lesions in the Female Rat Affect Sexual and Maternal Behavior and Their Sequential Organization
Autor: Afonso, Veronica M ; Sison, Margarette ; Lovic, Vedran ; Fleming, Alison S
Disterhoft, John F
Assuntos: Acoustic Stimulation - methods ; Analysis of Variance ; Animal ; Animal Maternal Behavior ; Animal reproduction ; Animal Sexual Behavior ; Animals ; Animals, Newborn ; Behavior, Animal ; Behavioral psychophysiology ; Biological and medical sciences ; Brain ; Brain damage ; Dose-Response Relationship, Radiation ; Exploratory Behavior ; Female ; Female Animals ; Fundamental and applied biological sciences. Psychology ; Inhibition (Psychology) ; Maternal Behavior - physiology ; Medial Prefrontal Cortex ; Motor Activity - physiology ; Motor Processes ; Neuropsychology ; Postpartum Period ; Prefrontal Cortex ; Prefrontal Cortex - injuries ; Prefrontal Cortex - physiology ; Pregnancy ; Prepulse Inhibition ; Psychobiology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Sprague-Dawley ; Reflex, Startle - physiology ; Rodents ; Sexual Behavior, Animal - physiology ; Time Factors
É parte de: Behavioral neuroscience, 2007-06, Vol.121 (3), p.515-526
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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Descrição: Temporal sequences of sexual and maternal behaviors in female rats and their correlation with each other and with performance on a sensory-motor gating response inhibition task assessed by prepulse inhibition (PPI) were investigated following medial prefrontal cortex (mPFC) lesions. Following excitotoxic mPFC ( n = 10) or sham ( n = 9) lesions, sexual behaviors across the ovarian cycle were scored. After mating and parturition, maternal interactions were scored until pups reached postnatal Day 10. After resumption of the ovarian cycle, the female rats were tested for PPI. Compared with sham lesions, mPFC lesions impaired proceptive behaviors and some maternal behaviors (e.g., pup retrieval, pup licking) but did not affect others (e.g., nest building, pup mouthing). Lesions disrupted temporal sequences of solicitations (number of male orientations followed, within 4 s, by a level change) and pup retrievals (number of pup retrievals followed, within 5 s, by another retrieval). These sequential behavior patterns were significantly correlated with each other and with PPI. However, when PPI effects were partialled out, group differences were less strong, but persisted. This study demonstrated that mPFC manipulations affect actions rich in sequential structure in response to biologically relevant stimuli.
Editor: Washington, DC: American Psychological Association
Idioma: Inglês

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Medial Prefrontal Cortex Lesions in the Female Rat Affect Sexual and Maternal Behavior and Their Sequential Organization

Afonso, Veronica M ; Sison, Margarette ; Lovic, Vedran ; Fleming, Alison S Disterhoft, John F

Washington, DC: American Psychological Association

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