Idioma:

Gestational diabetes and the human salivary microbiota: a longitudinal study during pregnancy and postpartum

Crusell, Mie K W ; Brink, Lærke R ; Nielsen, Trine ; Allin, Kristine H ; Hansen, Torben ; Damm, Peter ; Lauenborg, Jeannet ; Hansen, Tue H ; Pedersen, Oluf

BMC Pregnancy and Childbirth, 2020-01, Vol.20 (1), p.69-69, Article 69 [Periódico revisado por pares]

England: BioMed Central Ltd

Texto completo disponível

Citações Citado por

Enviar para

Título:
Gestational diabetes and the human salivary microbiota: a longitudinal study during pregnancy and postpartum
Autor: Crusell, Mie K W ; Brink, Lærke R ; Nielsen, Trine ; Allin, Kristine H ; Hansen, Torben ; Damm, Peter ; Lauenborg, Jeannet ; Hansen, Tue H ; Pedersen, Oluf
Assuntos: Antibiotics ; Bacterial species ; Biodiversity ; Composition ; Demographic aspects ; Deoxyribonucleic acid ; Development and progression ; Diabetes ; Diabetes mellitus ; DNA ; Fasting ; Genes ; Gestational diabetes ; Gestational diabetes mellitus ; Gestational hyperglycaemia ; Glucose ; Glycaemic traits ; Health aspects ; Hyperglycemia ; Immune system ; Insulin resistance ; Longitudinal studies ; Metabolic disorders ; Microbiota ; Microbiota (Symbiotic organisms) ; Preeclampsia ; Pregnancy ; Pregnant women ; Questionnaires ; Regression analysis ; Risk factors ; RNA ; Salivary diagnostics ; Salivary microbiota ; Type 2 diabetes ; Women ; Womens health
É parte de: BMC Pregnancy and Childbirth, 2020-01, Vol.20 (1), p.69-69, Article 69
Notas: SourceType-Other Sources-1
content type line 63
Descrição: An aberrant composition of the salivary microbiota has been found in individuals with type 2 diabetes, and in pregnant women salivary microbiota composition has been associated with preeclampsia and pre-term birth. Pregnant women, who develop gestational diabetes (GDM), have a high risk of developing type 2 diabetes after pregnancy. In the present study we assessed whether GDM is linked to variation in the oral microbial community by examining the diversity and composition of the salivary microbiota. In this observational study the salivary microbiota of pregnant women with GDM (n = 50) and normal glucose regulation (n = 160) in third trimester and 9 months postpartum was assessed by 16S rRNA gene amplicon sequencing of the V1-V3 region. GDM was diagnosed in accordance with the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria. Cross-sectional difference in alpha diversity was assessed using Student's t-test and longitudinal changes were assessed by mixed linear regression. Cross-sectional and longitudinal difference in beta diversity was assessed by permutational multivariate analyses of variance. Differentially abundant genera and OTUs were identified by negative binomial regression. In the third trimester, two species-level operational taxonomic units (OTUs), while eight OTUs postpartum were differentially abundant in women with GDM compared with normoglycaemic women. OTU richness, Shannon diversity and Pielou evenness decreased from late pregnancy to 9 months after delivery regardless of glycaemic status. GDM is associated with a minor aberration of the salivary microbiota during late pregnancy and postpartum. For unknown reasons richness of the salivary microbiota decreased from late pregnancy to postpartum, which might be explained by the physiological changes of the immune system during human pregnancy.
Editor: England: BioMed Central Ltd
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Gestational diabetes and the human salivary microbiota: a longitudinal study during pregnancy and postpartum

Crusell, Mie K W ; Brink, Lærke R ; Nielsen, Trine ; Allin, Kristine H ; Hansen, Torben ; Damm, Peter ; Lauenborg, Jeannet ; Hansen, Tue H ; Pedersen, Oluf

England: BioMed Central Ltd

Buscando em bases de dados remotas. Favor aguardar.