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Signaling Pathways Critical for Tooth Root Formation

Wang, J. ; Feng, J.Q.

Journal of Dental Research, 2017-10, Vol.96 (11), p.1221-1228 [Periódico revisado por pares]

Los Angeles, CA: SAGE Publications

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Título:
Signaling Pathways Critical for Tooth Root Formation
Autor: Wang, J. ; Feng, J.Q.
Assuntos: Animals ; beta Catenin - metabolism ; Cementum ; Dental Cementum - embryology ; Dental enamel ; Dentin ; Dentin - embryology ; Enamel ; Enamel Organ - embryology ; Families & family life ; Gene deletion ; Genes ; Genotype & phenotype ; Hedgehog Proteins - metabolism ; Humans ; Mice ; Mutation ; Nerve Tissue Proteins - metabolism ; NFI Transcription Factors - metabolism ; Nuclear factor I ; Odontogenesis - genetics ; Odontogenesis - physiology ; Orthodontics ; Population genetics ; Researchers ; Reviews ; Signal Transduction ; Sp7 Transcription Factor ; Stem cells ; Teeth ; Therapeutic applications ; Tooth Root - embryology ; Transcription Factors - metabolism ; Transgenic mice ; Wnt Proteins - metabolism ; β-Catenin
É parte de: Journal of Dental Research, 2017-10, Vol.96 (11), p.1221-1228
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Tooth is made of an enamel-covered crown and a cementum-covered root. Studies on crown dentin formation have been a major focus in tooth development for several decades. Interestingly, the population prevalence for genetic short root anomaly (SRA) with no apparent defects in crown is close to 1.3%. Furthermore, people with SRA itself are predisposed to root resorption during orthodontic treatment. The discovery of the unique role of Nfic (nuclear factor I C; a transcriptional factor) in controlling root but not crown dentin formation points to a new concept: tooth crown and root have different control mechanisms. Further genetic mechanism studies have identified more key molecules (including Osterix, β-catenin, and sonic hedgehog) that play a critical role in root formation. Extensive studies have also revealed the critical role of Hertwig’s epithelial root sheath in tooth root formation. In addition, Wnt10a has recently been found to be linked to multirooted tooth furcation formation. These exciting findings not only fill the critical gaps in our understanding about tooth root formation but will aid future research regarding the identifying factors controlling tooth root size and the generation of a whole “bio-tooth” for therapeutic purposes. This review starts with human SRA and mainly focuses on recent progress on the roles of NFIC-dependent and NFIC-independent signaling pathways in tooth root formation. Finally, this review includes a list of the various Cre transgenic mouse lines used to achieve tooth root formation–related gene deletion or overexpression, as well as strengths and limitations of each line.
Editor: Los Angeles, CA: SAGE Publications
Idioma: Inglês

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Signaling Pathways Critical for Tooth Root Formation

Wang, J. ; Feng, J.Q.

Los Angeles, CA: SAGE Publications

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