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A randomized, open‐label, multicenter study of the efficacy and safety of intravesical hyaluronic acid and chondroitin sulfate versus dimethyl sulfoxide in women with bladder pain syndrome/interstitial cystitis

Cervigni, Mauro ; Sommariva, Monica ; Tenaglia, Raffaele ; Porru, Daniele ; Ostardo, Edoardo ; Giammò, Alessandro ; Trevisan, Silvia ; Frangione, Valeria ; Ciani, Oriana ; Tarricone, Rosanna ; Pappagallo, Giovanni L.

Neurourology and urodynamics, 2017-04, Vol.36 (4), p.1178-1186 [Peer Reviewed Journal]

United States: Wiley Subscription Services, Inc

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Title:
A randomized, open‐label, multicenter study of the efficacy and safety of intravesical hyaluronic acid and chondroitin sulfate versus dimethyl sulfoxide in women with bladder pain syndrome/interstitial cystitis
Author: Cervigni, Mauro ; Sommariva, Monica ; Tenaglia, Raffaele ; Porru, Daniele ; Ostardo, Edoardo ; Giammò, Alessandro ; Trevisan, Silvia ; Frangione, Valeria ; Ciani, Oriana ; Tarricone, Rosanna ; Pappagallo, Giovanni L.
Subjects: Administration, Intravesical ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; bladder pain syndrome ; Chondroitin sulfate ; Chondroitin Sulfates - administration & dosage ; Chondroitin Sulfates - economics ; Cost analysis ; Cost-Benefit Analysis ; Cystitis ; Cystitis, Interstitial - complications ; Cystitis, Interstitial - drug therapy ; Cystitis, Interstitial - economics ; Dimethyl sulfoxide ; Dimethyl Sulfoxide - administration & dosage ; Dimethyl Sulfoxide - economics ; DMSO ; Female ; Humans ; Hyaluronic acid ; Hyaluronic Acid - administration & dosage ; Hyaluronic Acid - economics ; Ialuril ; interstitial cystitis ; Middle Aged ; Motivation ; Pain ; Pain - drug therapy ; Pain - etiology ; Pain Measurement ; Quality of Life ; Sulfates ; Treatment Outcome ; Urinary bladder ; Urinary Bladder - drug effects ; Urological Agents - administration & dosage ; Urological Agents - economics ; Young Adult
Is Part Of: Neurourology and urodynamics, 2017-04, Vol.36 (4), p.1178-1186
Notes: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-News-3
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Description: AIMS Intravesical instillation of hyaluronic acid (HA) plus chondroitin sulfate (CS) in women with bladder pain syndrome/interstitial cystitis (BPS/IC) has shown promising results. This study compared the efficacy, safety, and costs of intravesical HA/CS (Ialuril®, IBSA) to dimethyl sulfoxide (DMSO). METHODS Randomized, open‐label, multicenter study involving 110 women with BPS/IC. The allocation ratio (HA/CS:DMSO) was 2:1. Thirteen weekly instillations of HA (1.6%)/CS (2.0%) or 50% DMSO were given. Patients were evaluated at 3 (end‐of‐treatment) and 6 months. Primary endpoint was reduction in pain intensity at 6 months by visual analogue scale (VAS) versus baseline. Secondary efficacy measurements were quality of life and economic analyses. RESULTS A significant reduction in pain intensity was observed at 6 months in both treatment groups versus baseline (P < 0.0001) in the intention‐to‐treat population. Treatment with HA/CS resulted in a greater reduction in pain intensity at 6 months compared with DMSO for the per‐protocol population (mean VAS reduction 44.77 ± 25.07 vs. 28.89 ± 31.14, respectively; P = 0.0186). There were no significant differences between treatment groups in secondary outcomes. At least one adverse event was reported in 14.86% and 30.56% of patients in the HA/CS and DMSO groups, respectively. There were significantly fewer treatment‐related adverse events for HA/CS versus DMSO (1.35% vs. 22.22%; P = 0.001). Considering direct healthcare costs, the incremental cost‐effectiveness ratio of HA/CS versus DMSO fell between 3735€/quality‐adjusted life years (QALY) and 8003€/QALY. CONCLUSIONS Treatment with HA/CS appears to be as effective as DMSO with a potentially more favorable safety profile. Both treatments increased health‐related quality of life, while HA/CS showed a more acceptable cost‐effectiveness profile.
Publisher: United States: Wiley Subscription Services, Inc
Language: English

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A randomized, open‐label, multicenter study of the efficacy and safety of intravesical hyaluronic acid and chondroitin sulfate versus dimethyl sulfoxide in women with bladder pain syndrome/interstitial cystitis

Cervigni, Mauro ; Sommariva, Monica ; Tenaglia, Raffaele ; Porru, Daniele ; Ostardo, Edoardo ; Giammò, Alessandro ; Trevisan, Silvia ; Frangione, Valeria ; Ciani, Oriana ; Tarricone, Rosanna ; Pappagallo, Giovanni L.

United States: Wiley Subscription Services, Inc

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